ReviewThe Journal of physiology2002
Transport of volatile solutes through AQP1.
Review in The Journal of physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 107 citations in OpenAlex.
- Impact of Lipid Composition on Membrane Partitioning and Permeability of Gas Molecules.Membranes · 2026Article
- Ammonia transport mediated by urea transporter A isoforms.Biology open · 2025Article
- Non-coding RNAs and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders.Neurochemical research · 2024Review
- Protein Structure and Modification of Aquaporins.Advances in experimental medicine and biology · 2023Article
- Regulation of glomerulotubular balance. IV. Implication of aquaporin 1 in flow-dependent proximal tubule transport and cell volume.American journal of physiology. Renal physiology · 2022Article
- Carbon dioxide transport across membranes.Interface focus · 2021Review
- Longitudinal [NeuroImage. Clinical · 2021Article
- Transcriptomic response to three osmotic stresses in gills of hybrid tilapia (Oreochromis mossambicus female × O. urolepis hornorum male).BMC genomics · 2020Article
- CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels.The Journal of physiology · 2015Article
- pH sensing and regulation in cancer.Frontiers in physiology · 2013Review
- Transport of H2S and HS(-) across the human red blood cell membrane: rapid H2S diffusion and AE1-mediated Cl(-)/HS(-) exchange.American journal of physiology. Cell physiology · 2013Article
- Molecular dynamics of water in the neighborhood of aquaporins.European biophysics journal : EBJ · 2013Review
- Sharpey-Schafer lecture: gas channels.Experimental physiology · 2010Article
- Aquaporin tetramer composition modifies the function of tobacco aquaporins.The Journal of biological chemistry · 2010Article
- Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology.Antioxidants & redox signaling · 2010Review
- Aquaporin biology and nervous system.Current neuropharmacology · 2010Article
- Exploring transmembrane diffusion pathways with molecular dynamics.Physiology (Bethesda, Md.) · 2010Review
- Nitric oxide conduction by the brain aquaporin AQP4.Proteins · 2010Article
- Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO2, NH3, and NH4(+), is necessary for acid survival of Helicobacter pylori.Journal of bacteriology · 2010Article
- Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression.American journal of physiology. Renal physiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
For almost a century it was generally assumed that the lipid phases of all biological membranes are freely permeable to gases. However, recent observations challenge this dogma. The apical membranes of epithelial cells exposed to hostile environments, such as gastric glands, have no demonstrable permeability to the gases CO2 and NH3. Additionally, the water channel protein aquaporin 1 (AQP1), expressed at high levels in erythrocytes, can increase membrane CO2 permeability when expressed in Xenopus oocytes. Similarly, nodulin-26, which is closely related to AQP1, can act as a conduit for NH3. A key question is whether aquaporins, which are abundant in virtually every tissue that transports O2 and CO2 at high levels, ever play a physiologically significant role in the transport of small volatile molecules. Preliminary data are consistent with the hypothesis that AQP1 enhances the reabsorption of HCO3- by the renal proximal tubule by increasing the CO2 permeability of the apical membrane. Other preliminary data on Xenopus oocytes heterologously expressing the electrogenic Na+-HCO3- cotransporter (NBC), AQP1 and carbonic anhydrases are consistent with the hypothesis that the macroscopic cotransport of Na+ plus two HCO3- occurs as NBC transports Na+ plus CO3(2-) and AQP1 transports CO2 and H2O. Although data - obtained on AQP1 reconstituted into liposomes or on materials from AQP1 knockout mice - appear inconsistent with the model that AQP1 mediates substantial CO2 transport in certain preparations, the existence of unstirred layers or perfusion-limited conditions may have masked the contribution of AQP1 to CO2 permeability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.