ReviewCurrent pain and headache reports2002
Peripheral and central sensitization in fibromyalgia: pathogenetic role.
Review in Current pain and headache reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home-based Transcranial Direct Current Stimulation in Fibromyalgia Patients. Phase II, Randomized, Double-blind, Single-center Clinical Trial
Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Pooled it
- Coordinate-based meta-analysis of experimentally induced and chronic persistent neuropathic pain.NeuroImage · 2011Pooled it
- The efficacy of a telerehabilitation-based clinical Pilates program on lumbopelvic muscle morphology and strength in female patients with fibromyalgia syndrome: a randomized controlled trial.Clinical rheumatology · 2025Trial
- Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia.Arthritis research & therapy · 2016Trial
- Trial
- Dysfunctional pain inhibition in patients with chronic whiplash-associated disorders: an experimental study.Clinical rheumatology · 2013Trial
- Trial
- Psychosocial correlates of central sensitization and kinesiophobia: the role of Type D personality in fibromyalgia - a cross-sectional study.BMC musculoskeletal disorders · 2026Article
- Corneal confocal microscopy in fibromyalgia syndrome: small fiber neuropathy, and treatment outcomes.Eye (London, England) · 2026Article
- Non-Cyclical Mastalgia as a Central Sensitization Component: Implications for Multidisciplinary Treatment Approaches.Brain and behavior · 2025Article
- Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations.Translational psychiatry · 2025Review
- Repetitive transcranial magnetic stimulation at low frequency for the treatment of fibromyalgia. Results from the first treatment cohort at the brainwave clinic.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Epidemiological and clinical profile of fibromyalgia in Congolese patients at the university hospital of Kinshasa: a descriptive hospital-based study.The Pan African medical journal · 2025Article
- Cervical and Ocular Vestibular Evoked Myogenic Potentials in Fibromyalgia Syndrome Patients.The journal of international advanced otology · 2024Article
- Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions.International journal of molecular sciences · 2023Review
- Motor Cortex Inhibition and Facilitation Correlates with Fibromyalgia Compensatory Mechanisms and Pain: A Cross-Sectional Study.Biomedicines · 2023Article
- Central Sensitization and Chronic Pain Personality Profile: Is There New Evidence? A Case-Control Study.International journal of environmental research and public health · 2023Article
- Diagnostic difficulty, delayed diagnosis, and increased tendencies of surgical treatment in fibromyalgia syndrome.Clinical rheumatology · 2022Article
- Relevance of Religiosity for Coping Strategies and Disability in Patients with Fibromyalgia Syndrome.Journal of religion and health · 2022Article
- Neural activation changes in response to pain following cognitive behavioral therapy for patients with comorbid fibromyalgia and insomnia: a pilot study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characteristic symptoms of fibromyalgia syndrome include widespread pain, fatigue, sleep abnormalities, and distress. Patients with fibromyalgia show psychophysical evidence of mechanical, thermal, and electrical hyperalgesia. Peripheral and central abnormalities of nociception have been described in fibromyalgia. Important nociceptor systems in the skin and muscles seem to undergo profound changes in patients with fibromyalgia through unknown mechanisms. They include sensitization of vanilloid receptor, acid-sensing ion channel receptors, and purino-receptors. Tissue mediators of inflammation and nerve growth factors can excite these receptors and cause extensive changes in pain sensitivity, but patients with fibromyalgia lack consistent evidence for inflammatory soft tissue abnormalities. Therefore, recent investigations have focused on central nervous system mechanisms of pain in fibromyalgia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.