ArticleBMC cell biology2002
Nucleolar localization of an isoform of the IGF-I precursor.
Article in BMC cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- The role of mechano growth factor in chondrocytes and cartilage defects: a concise review.Acta biochimica et biophysica Sinica · 2023Review
- Role of Alternatively Spliced Messenger RNA (mRNA) Isoforms of the Insulin-Like Growth Factor 1 (IGF1) in Selected Human Tumors.International journal of molecular sciences · 2020Review
- The intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion.Scientific reports · 2018Article
- Human IGF-I propeptide A promotes articular chondrocyte biosynthesis and employs glycosylation-dependent heparin binding.Biochimica et biophysica acta. General subjects · 2018Article
- Immunohistochemical analysis of insulin-like growth factor 1 and its receptor in sporadic schwannoma/peripheral nerve sheath tumour.The Journal of international medical research · 2016Article
- IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (review).Oncology reports · 2014Review
- IGF expression in HPV-related and HPV-unrelated human cancer cells.Oncology reports · 2014Article
- The costimulatory molecule B7-H4 promote tumor progression and cell proliferation through translocating into nucleus.Oncogene · 2013Article
- Human Eb peptide: not just a by-product of pre-pro-IGF1b processing?Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2013Article
- Article
- Insulin-like growth factor I (IGF-1) Ec/Mechano Growth factor--a splice variant of IGF-1 within the growth plate.PloS one · 2013Article
- New Modulators for IGF-I Activity within IGF-I Processing Products.Frontiers in endocrinology · 2013Article
- The Regulation of IGF-1 Gene Transcription and Splicing during Development and Aging.Frontiers in endocrinology · 2013Article
- Expression of various insulin-like growth factor-1 mRNA isoforms in colorectal cancer.Contemporary oncology (Poznan, Poland) · 2012Article
- Mechano-Growth Factor: an important cog or a loose screw in the repair machinery?Frontiers in endocrinology · 2012Article
- IGF1 mRNA isoform expression in the cervix of HPV-positive women with pre-cancerous and cancer lesions.Experimental and therapeutic medicine · 2011Article
- The insulin-like growth factor (IGF)-I E-peptides modulate cell entry of the mature IGF-I protein.Molecular biology of the cell · 2009Article
- Subcellular localization of CIAPIN1.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
BACKGROUND Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differently. Chimeric IGF-I precursors were made with green fluorescent protein (GFP) cloned between the signal and mature IGF-I domains. RESULTS Chimeras containing exons 1 or 2 were located in the cytoplasm, consistent with a secretory pathway, and suggesting that both exons encoded functional signal peptides. Exon 5-containing chimeras localized to the nucleus and strongly to the nucleolus, while chimeras containing exon 6 or the upstream portion of exon 5 did not. Nuclear and nucleolar localization also occurred when the mature IGF-I domain was deleted from the chimeras, or when signal peptides were deleted. CONCLUSIONS We have identified a nucleolar localization for an isoform of the human IGF-I precursor. The findings are consistent with the presence of a nuclear and nucleolar localization signal situated in the C-terminal part of the exon 5-encoded domain with similarities to signals in several other growth factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.