ArticleNeuromolecular medicine2002
PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor.
Article in Neuromolecular medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- In vivo functions of p75Trends in pharmacological sciences · 2021Review
- Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis.Biomolecules · 2021Article
- Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action.PLoS biology · 2014Article
- P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.PloS one · 2013Article
- Understanding proneurotrophin actions: Recent advances and challenges.Developmental neurobiology · 2010Review
- NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death.The EMBO journal · 2009Article
- A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- A pro-apoptotic fragment of the p75 neurotrophin receptor is expressed in p75NTRExonIV null mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Receptor-mediated choreography of life and death.Journal of clinical immunology · 2003Review
- Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We describe the cloning and characterization of a rat single transmembrane protein that is homologous to the common neurotrophin receptor p75NTR in its death domain and the transmembrane region but dissimilar outside these regions. We have dubbed this protein PLAIDD, for p75-like apoptosis-inducing death domain protein. PLAIDD messenger RNA, which is ubiquitously distributed, is highly expressed in the embryo, but downregulated in adult tissues. Alternative splicing within the extracellular region of PLAIDD generates four RNA species, but only two of them are translated, PLAIDD_L and PLAIDD_S (long and short isoforms, respectively). While the amino acid sequence of the intracellular region of PLAIDD displays 41% identity with the intracellular region of p75NTR, the extracellular region of PLAIDD does not reveal any homology with p75NTR. Overexpression of each isoform of PLAIDD led to cytotoxicity in superior cervical ganglion neurons and in human embryonic kidney 293T cells. Both isoforms of PLAIDD could be co-immunoprecipitated with p75NTR, suggesting an interaction between these molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.