ReviewInternational journal of hematology2002
The notch pathway: modulation of cell fate decisions in hematopoiesis.
Review in International journal of hematology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Significance of Notch Signaling in Salivary Gland Development and Diseases.Journal of clinical medicine · 2025Review
- Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs.Stem cell reports · 2023Article
- The Notch signaling pathway involvement in innate lymphoid cell biology.Biomedical journal · 2021Review
- Physiological Cues Involved in the Regulation of Adhesion Mechanisms in Hematopoietic Stem Cell Fate Decision.Frontiers in cell and developmental biology · 2020Review
- Producing proT cells to promote immunotherapies.International immunology · 2018Review
- [Effect of endothelial cell-targeted soluble Notch ligand hD1R protein on the proliferation of acute myeloid leukemia cells].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2018Article
- Targeting Notch signalling pathway of cancer stem cells.Stem cell investigation · 2018Review
- Anabolic actions of Notch on mature bone.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis.Annals of the New York Academy of Sciences · 2015Review
- Over-expression of hNGF in adult human olfactory bulb neural stem cells promotes cell growth and oligodendrocytic differentiation.PloS one · 2013Article
- Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- Gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra.PloS one · 2011Article
- RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer.Neural development · 2010Article
- Article
- Hematopoietic niche and bone meet.Current opinion in supportive and palliative care · 2008Review
- Communications between bone cells and hematopoietic stem cells.Archives of biochemistry and biophysics · 2008Review
- Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands.Blood · 2007Article
- Notch signaling in hematopoietic stem cells.International journal of hematology · 2005Review
- A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia.Molecular and cellular biology · 2004Article
- Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents.Oncogene · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The hematopoietic system is maintained by a rare population of hematopoietic stem cells (HSC) that are thought to undergo self-renewal as well as continuously produce progeny that differentiate into the various hematopoietic lineages. However, the mechanisms regulating cell fate choices by HSC and their progeny have not been understood. Results of most studies support a stochastic model of cell fate determination in which growth factors support only the survival or proliferation of the progeny specified along a particular lineage. In other developmental systems, however, Notch signaling has been shown to play a central role in regulating fate decisions of numerous types of precursors, often inhibiting a particular (default) pathway while permitting self-renewal or differentiation along an alternative pathway. There is also accumulating evidence that the Notch pathway affects survival, proliferation, and cell fate choices at various stages of hematopoietic cell development, including the decisions of HSC to self-renew or differentiate and of common lymphoid precursors to undergo T- or B-cell differentiation. These data suggest that the Notch pathway plays a fundamental role in the development and maintenance of the hematopoietic system.
Indexed as
Identifiers
12095143What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.