ArticleAmerican journal of human genetics2002
Molecular characterization of the pericentric inversion that causes differences between chimpanzee chromosome 19 and human chromosome 17.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 75 citations in OpenAlex.
- Complete sequencing of ape genomes.Nature · 2025Article
- Complete sequencing of ape genomes.bioRxiv : the preprint server for biology · 2024Article
- Genomic Organization of Microsatellites andAnimals : an open access journal from MDPI · 2022Article
- Differences between human and chimpanzee genomes and their implications in gene expression, protein functions and biochemical properties of the two species.BMC genomics · 2020Review
- Novel H3K4me3 marks are enriched at human- and chimpanzee-specific cytogenetic structures.Genome research · 2014Article
- The heterochromatic chromosome caps in great apes impact telomere metabolism.Nucleic acids research · 2013Article
- De novo inv(17)(p11.2q21.3) in an intellectually disabled girl: appraisal of 21 inv(17) constitutional instances.Journal of genetics · 2012Article
- The origins and impact of primate segmental duplications.Trends in genetics : TIG · 2009Review
- Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites.Genome research · 2009Article
- Sequencing primate genomes: what have we learned?Annual review of genomics and human genetics · 2009Review
- Quantitative variation of LINE-1 sequences in five species and three subspecies of the subgenus Mus and in five Robertsonian races of Mus musculus domesticus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements.BMC genomics · 2008Article
- Molecular mechanisms of chromosomal rearrangement during primate evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
- Hominoid chromosomal rearrangements on 17q map to complex regions of segmental duplication.Genome biology · 2008Article
- Article
- Construction, characterization, and chromosomal mapping of a fosmid library of the white-cheeked gibbon (Nomascus leucogenys).Genomics, proteomics & bioinformatics · 2007Article
- Structural divergence between the human and chimpanzee genomes.Human genetics · 2007Review
- On the association between chromosomal rearrangements and genic evolution in humans and chimpanzees.Genome biology · 2007Article
- A high-resolution map of synteny disruptions in gibbon and human genomes.PLoS genetics · 2006Article
- Characterization of the human lineage-specific pericentric inversion that distinguishes human chromosome 1 from the homologous chromosomes of the great apes.Human genetics · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comparison of the human genome with that of the chimpanzee is an attractive approach to attempts to understand the specificity of a certain phenotype's development. The two karyotypes differ by one chromosome fusion, nine pericentric inversions, and various additions of heterochromatin to chromosomal telomeres. Only the fusion, which gave rise to human chromosome 2, has been characterized at the sequence level. During the present study, we investigated the pericentric inversion by which chimpanzee chromosome 19 differs from human chromosome 17. Fluorescence in situ hybridization was used to identify breakpoint-spanning bacterial artificial chromosomes (BACs) and plasmid artificial chromosomes (PACs). By sequencing the junction fragments, we localized breakpoints in intergenic regions rich in repetitive elements. Our findings suggest that repeat-mediated nonhomologous recombination has facilitated inversion formation. No addition or deletion of any sequence element was detected at the breakpoints or in the surrounding sequences. Next to the break, at a distance of 10.2-39.1 kb, the following genes were found: NGFR and NXPH3 (on human chromosome 17q21.3) and GUC2D and ALOX15B (on human chromosome 17p13). The inversion affects neither the genomic structure nor the gene-activity state with regard to replication timing of these genes.
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