ArticleLeukemia2002
Chromosomal imbalances in familial chronic lymphocytic leukaemia: a comparative genomic hybridisation analysis.
Article in Leukemia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Familial chronic lymphocytic leukemia in two siblings with ATM/13q14 deletion and a similar pattern of clonal evolution.Blood cancer journal · 2015Article
- Familial leukemias.Current treatment options in oncology · 2015Review
- Genomic approaches to chronic lymphocytic leukemia.Hematology/oncology clinics of North America · 2013Review
- Evidences showing wide presence of small genomic aberrations in chronic lymphocytic leukemia.BMC research notes · 2010Article
- Comparison of familial and sporadic chronic lymphocytic leukaemia using high resolution array comparative genomic hybridization.British journal of haematology · 2010Article
- Inherited predisposition to chronic lymphocytic leukemia.Expert review of hematology · 2008Review
- Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.American journal of human genetics · 2008Article
- Chronic lymphocytic leukaemia: clinical-aetiological findings in 66 patients and their families.Hereditary cancer in clinical practice · 2007Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A subset of B cell chronic lymphocytic leukaemia (CLL) is familial. Lack of large families makes it attractive to exploit methods in addition to genetic linkage analysis for the identification of a susceptibility locus. One strategy that can localise regions of the genome that may harbour tumour suppressor genes is to identify regions of chromosomal imbalance using comparative genomic hybridisation (CGH) analysis. We examined 24 familial CLL cases by CGH analysis. Losses that are documented as arising frequently in sporadic CLL were observed at a comparable frequency in familial CLL. However, gains and losses in two regions of the X chromosome - Xp11.2-p21 and Xq21-qter - appear more common in familial CLL than in sporadic CLL. This suggests these regions may harbour a susceptibility locus for CLL. There is also some evidence that chromosome regions 2p12-p14 and 4q11-q21 may harbour predisposition genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.