ArticleThe Journal of experimental medicine2002
Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention.Molecular cancer · 2026Review
- Matrix-Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy.Journal of translational medicine · 2022Article
- The Selenoprotein MsrB1 Instructs Dendritic Cells to Induce T-Helper 1 Immune Responses.Antioxidants (Basel, Switzerland) · 2020Article
- Article
- Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi's Sarcoma-Associated Herpesvirus for Viral Latency.PLoS pathogens · 2017Article
- Solitary fibrous tumors: loss of chimeric protein expression and genomic instability mark dedifferentiation.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Serine protease inhibition attenuates rIL-12-induced GZMA activity and proinflammatory events by modulating the Th2 profile from estrogen-treated mice.Endocrinology · 2014Article
- Calpain-1 contributes to IgE-mediated mast cell activation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Non-genomic STAT5-dependent effects at the endoplasmic reticulum and Golgi apparatus and STAT6-GFP in mitochondria.JAK-STAT · 2013Review
- Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy.Mucosal immunology · 2013Article
- B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation.PloS one · 2011Article
- Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.The Journal of biological chemistry · 2010Article
- Article
- Purification and identification of the STAT5 protease in myeloid cells.The Biochemical journal · 2007Article
- Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.Immunology · 2005Review
- IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells.The Journal of experimental medicine · 2003Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence has shown the importance of Stat6-mediated signaling in allergic diseases. In this study, we show a novel regulatory mechanism of Stat6-mediated signaling in mast cells. When Stat6 is activated by interleukin (IL)-4 and translocated to the nucleus, Stat6 is cleaved by a nucleus-associated protease in mast cells. The cleaved 65-kD Stat6 lacks the COOH-terminal transactivation domain and functions as a dominant-negative molecule to Stat6-mediated transcription. The retrovirus-mediated expression of cleavage-resistant Stat6 mutants prolongs the nuclear accumulation of Stat6 upon IL-4 stimulation and enhances IL-4-induced gene expression and growth inhibition in mast cells. These results indicate that the proteolytic processing of Stat6 functions as a lineage-specific negative regulator of Stat6-dependent signaling in mast cells, and thus suggest that it may account for the limited role of Stat6 in IL-4 signaling in mast cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.