ArticleThe EMBO journal2002
Drosophila cyclin E interacts with components of the Brahma complex.
Article in The EMBO journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
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- Chrysophanol Induced Glioma Cells Apoptosis via Activation of Mitochondrial Apoptosis Pathway.Bioengineered · 2021Article
- Kinome-Wide RNAi Screen Uncovers Role of Ballchen in Maintenance of Gene Activation by Trithorax Group inFrontiers in cell and developmental biology · 2021Article
- Phosphorylation of Drosophila Brahma on CDK-phosphorylation sites is important for cell cycle regulation and differentiation.Cell cycle (Georgetown, Tex.) · 2018Article
- Modelling Cooperative Tumorigenesis inBioMed research international · 2018Review
- The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.EMBO reports · 2015Article
- The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.eLife · 2014Article
- In vivo regulation of E2F1 by Polycomb group genes in Drosophila.G3 (Bethesda, Md.) · 2012Article
- Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen.G3 (Bethesda, Md.) · 2012Article
- Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3.Development (Cambridge, England) · 2012Article
- Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells.Molecular pharmacology · 2010Article
- The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs.Genetics · 2010Article
- The SWI/SNF complex and cancer.Oncogene · 2009Review
- Identification of novel regulators of atonal expression in the developing Drosophila retina.Genetics · 2008Article
- Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development.Molecular and cellular biology · 2008Article
- Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway.Nucleic acids research · 2008Article
- Article
- Transdetermination: Drosophila imaginal disc cells exhibit stem cell-like potency.The international journal of biochemistry & cell biology · 2007Review
- Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control.Molecular and cellular biology · 2007Article
- dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX.The Biochemical journal · 2006Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclin E-Cdk2 is essential for S phase entry. To identify genes interacting with cyclin E, we carried out a genetic screen using a hypomorphic mutation of Drosophila cyclin E (DmcycE(JP)), which gives rise to adults with a rough eye phenotype. Amongst the dominant suppressors of DmcycE(JP), we identified brahma (brm) and moira (mor), which encode conserved core components of the Drosophila Brm complex that is highly related to the SWI-SNF ATP-dependent chromatin remodeling complex. Mutations in genes encoding other Brm complex components, including snr1 (BAP45), osa and deficiencies that remove BAP60 and BAP111 can also suppress the DmcycE(JP) eye phenotype. We show that Brm complex mutants suppress the DmcycE(JP) phenotype by increasing S phases without affecting DmcycE protein levels and that DmcycE physically interacts with Brm and Snr1 in vivo. These data suggest that the Brm complex inhibits S phase entry by acting downstream of DmcycE protein accumulation. The Brm complex also physically interacts weakly with Drosophila retinoblastoma (Rbf1), but no genetic interactions were detected, suggesting that the Brm complex and Rbf1 act largely independently to mediate G(1) arrest.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.