ArticleGenome biology2002
Estimation of genetic distances from human and mouse introns.
Article in Genome biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- Development of rapidly evolving intron markers to estimate multilocus species trees of rodents.PloS one · 2014Article
- FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.RNA (New York, N.Y.) · 2013Article
- Novel intron markers to study the phylogeny of closely related mammalian species.BMC evolutionary biology · 2010Article
- Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis.Molecular biology reports · 2009Article
- Spliceosomal introns as tools for genomic and evolutionary analysis.Nucleic acids research · 2008Review
- Further understanding human disease genes by comparing with housekeeping genes and other genes.BMC genomics · 2006Article
- Localization, structure and polymorphism of two paralogous Xenopus laevis mitochondrial malate dehydrogenase genes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Article
- Organization of the MASP2 locus and its expression profile in mouse and rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Clustering of genes coding for DNA binding proteins in a region of atypical evolution of the human genome.Journal of molecular evolution · 2004Article
- Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile.Genome research · 2004Article
- Modeling DNA base substitution in large genomic regions from two organisms.Journal of molecular evolution · 2004Article
- Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution.Genome research · 2003Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUsing genetic distances measured from exons, it has been observed that the mutation rate is not constant along mammalian chromosomes. Exons constitute only 1% of the human genome, however, and thus they cannot provide a complete picture of the mutational variation in the genome.
resultsI calculated genetic distances between 504 human introns and their orthologous mouse counterparts from a set of 63 pairs of human and mouse genes scattered through the genome using a recently developed method that can extract reliably aligned regions from the introns in an objective manner. I found a significant correlation between the genetic distance measured in the conserved intron segments and the synonymous and nonsynonymous distances measured in the corresponding coding exons, indicating that genes with fast-evolving exons tend to have fast-evolving introns, and vice versa.
conclusionsThese results indicate that introns, which extend over almost a quarter of the human genome, contain useful information for fully understanding the mutational dynamics of human and mouse genomes. This work also supports the idea that there is a mutational force that fluctuates nonrandomly along the genome, and shows for the first time that this force affects the introns and the synonymous and nonsynonymous positions in the exons of the genes simultaneously.
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