ArticleNature immunology2002
Positive selection of MHC class Ib-restricted CD8(+) T cells on hematopoietic cells.
Article in Nature immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed.
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Review
- Cytokine receptor γc effectuates the generation of proinflammatory innate CD8 T cells by non-classical MHC-I molecules.Journal of autoimmunity · 2023Article
- Virtual Memory CD8Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Review
- Review
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1Frontiers in immunology · 2018Article
- A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors.The Journal of biological chemistry · 2017Article
- Lineage Differentiation Program of Invariant Natural Killer T Cells.Immune network · 2017Review
- Antigen Processing in the Endoplasmic Reticulum Is Monitored by Semi-Invariant αβ TCRs Specific for a Conserved Peptide-Qa-1Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases.Frontiers in immunology · 2017Article
- The role of MHC class Ib-restricted T cells during infection.Immunogenetics · 2016Review
- Thymic low affinity/avidity interaction selects natural Th1 cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis.Immunological reviews · 2015Review
- Evolution of nonclassical MHC-dependent invariant T cells.Cellular and molecular life sciences : CMLS · 2014Review
- A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles.Immunogenetics · 2014Review
- Expression of the mouse MHC class Ib H2-T11 gene product, a paralog of H2-T23 (Qa-1) with shared peptide-binding specificity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors.Frontiers in immunology · 2014Article
- Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byBlood lines.2002
Authors and funding
3 authors.
Funding
Abstract
Unlike conventional CD8(+) T cells, major histocompatibility complex (MHC) class Ib-restricted CD8(+) T cells show an activated phenotype in uninfected mice and respond rapidly to foreign invaders. The underlying factors that contribute to these differences are not well understood. We show here that the activated phenotype of MHC class Ib-restricted CD8(+) T cells was partially acquired as a result of interactions in the thymus and reflected an increased capacity to be selected via interactions with MHC molecules on hematopoietic cells. Using bone marrow-chimeric mice, we have shown that MHC class Ib-restricted, but not MHC class Ia-restricted, CD8(+) T cells specific for Listeria monocytogenes were efficiently selected when MHC class I was expressed only on hematopoietic cells. Thus, the distinct functional properties of MHC class Ib-restricted versus MHC class Ia-restricted CD8(+) T cells may result, at least in part, from the different ways in which they are positively selected in the thymus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.