ArticleProceedings of the National Academy of Sciences of the United States of America2002
Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Meta-analysis of Drosophila circadian microarray studies identifies a novel set of rhythmically expressed genes.PLoS computational biology · 2007Pooled it
- Brain Transcriptomics Across Diverse Sleep-Wake Manipulations Reveals Multiple Homeostatic Pathways inbioRxiv : the preprint server for biology · 2026Article
- Review
- Time-Series RNA Sequencing Reveals Temperature-Specific and Temperature-Compensated Circadian Genes inbioRxiv : the preprint server for biology · 2025Article
- Article
- Nonlinear expression patterns and multiple shifts in gene network interactions underlie robust phenotypic change in Drosophila melanogaster selected for night sleep duration.PLoS computational biology · 2023Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Identification of Genes Contributing to a Long Circadian Period inJournal of biological rhythms · 2021Article
- Time of Day-Specific Changes in Metabolic Detoxification and Insecticide Tolerance in the House Fly,Frontiers in physiology · 2021Article
- Genome-wide discovery of the daily transcriptome, DNA regulatory elements and transcription factor occupancy in the monarch butterfly brain.PLoS genetics · 2019Article
- Article
- Reflections on contributing to "big discoveries" about the fly clock: Our fortunate paths as post-docs with 2017 Nobel laureates Jeff Hall, Michael Rosbash, and Mike Young.Neurobiology of sleep and circadian rhythms · 2018Review
- Circadian regulation of metabolism and healthspan in Drosophila.Free radical biology & medicine · 2018Review
- Changes in Neuronal Signaling and Cell Stress Response Pathways are Associated with a Multigenic Response of Drosophila melanogaster to DDT Selection.Genome biology and evolution · 2017Article
- Circadian Rhythms and Sleep inGenetics · 2017Review
- Article
- period-Regulated Feeding Behavior and TOR Signaling Modulate Survival of Infection.Current biology : CB · 2016Article
- Identification and functional analysis of early gene expression induced by circadian light-resetting in Drosophila.BMC genomics · 2015Article
- Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data.PLoS computational biology · 2015Article
- A Stochastic Burst Follows the Periodic Morning Peak in Individual Drosophila Locomotion.PloS one · 2015Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
We measured daily gene expression in heads of control and period mutant Drosophila by using oligonucleotide microarrays. In control flies, 72 genes showed diurnal rhythms in light-dark cycles; 22 of these also oscillated in free-running conditions. The period gene significantly influenced the expression levels of over 600 nonoscillating transcripts. Expression levels of several hundred genes also differed significantly between control flies kept in light-dark versus constant darkness but differed minimally between per(01) flies kept in the same two conditions. Thus, the period-dependent circadian clock regulates only a limited set of rhythmically expressed transcripts. Unexpectedly, period regulates basal and light-regulated gene expression to a very broad extent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.