ArticleJournal of clinical microbiology2002
Comparison of an assay using signal amplification of the heat-dissociated p24 antigen with the Roche Monitor human immunodeficiency virus RNA assay.
Article in Journal of clinical microbiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Lack of longitudinal intrapatient correlation between p24 antigenemia and levels of human immunodeficiency virus (HIV) type 1 RNA in patients with chronic hiv infection during structured treatment interruptions.Journal of clinical microbiology · 2004Trial
- Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection.Journal of virology · 2021Article
- p24 revisited: a landscape review of antigen detection for early HIV diagnosis.AIDS (London, England) · 2018Review
- Increased Sensitivity of HIV-1 p24 ELISA Using a Photochemical Signal Amplification System.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Poor performance of the determine HIV-1/2 Ag/Ab combo fourth-generation rapid test for detection of acute infections in a National Household Survey in Swaziland.Journal of clinical microbiology · 2014Article
- Detection of acute HIV infection: a field evaluation of the determine® HIV-1/2 Ag/Ab combo test.The Journal of infectious diseases · 2012Article
- Low-cost assays for monitoring HIV infected individuals in resource-limited settings.The Indian journal of medical research · 2011Review
- Diagnostic accuracy of ultrasensitive heat-denatured HIV-1 p24 antigen in non-B subtypes in Kampala, Uganda.International journal of STD & AIDS · 2011Article
- Performance characteristics of the Cavidi ExaVir viral load assay and the ultra-sensitive P24 assay relative to the Roche Monitor HIV-1 RNA assay.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010Article
- Detection of individuals with acute HIV-1 infection using the ARCHITECT HIV Ag/Ab Combo assay.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- Detection of HIV-1 p24 Gag in plasma by a nanoparticle-based bio-barcode-amplification method.Nanomedicine (London, England) · 2008Article
- SMARThivVLmos: a complexity-free and cost effective dynamic model technology for monitoring HIV viral load in resource-poor settings.Bioinformation · 2008Article
- Potential of a simplified p24 assay for early diagnosis of infant human immunodeficiency virus type 1 infection in Haiti.Journal of clinical microbiology · 2007Article
- HIV-1 viral load assays for resource-limited settings.PLoS medicine · 2006Review
- Comparison of two human immunodeficiency virus (HIV) RNA surrogate assays to the standard HIV RNA assay.Journal of clinical microbiology · 2005Article
- Detection and quantification of human immunodeficiency virus type 1 p24 antigen in dried whole blood and plasma on filter paper stored under various conditions.Journal of clinical microbiology · 2005Article
- Evaluation of an ultrasensitive p24 antigen assay as a potential alternative to human immunodeficiency virus type 1 RNA viral load assay in resource-limited settings.Journal of clinical microbiology · 2005Article
- Pediatric human immunodeficiency virus screening in an African district hospital.Clinical and diagnostic laboratory immunology · 2005Article
- Advances in developing HIV-1 viral load assays for resource-limited settings.Biotechnology advancesReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We compared an assay using signal amplification of a heat-dissociated p24 antigen (HDAg) with the Roche Monitor human immunodeficiency virus (HIV) RNA assay. The two assays gave comparable results when 130 specimens from 130 patients were tested (r = 0.60, P < 0.0001). The HDAg assay was almost as sensitive (85%) as the Roche HIV RNA kit (95%), just as specific (25 negative results from 25 HIV seronegative volunteers [100%]), less variable (mean log standard deviation of 0.07 compared to 0.11 when eight specimens were tested three or four times), and less expensive (reagent and labor costs, $8 versus $75). The assay appeared to be useful for monitoring established patients (n = 17) and identifying seroconverters (n = 4). HIV subtypes A to F were all recognized. This assay should be useful for monitoring patients in resource-poor countries and for monitoring vaccine recipients.
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