Risk factor thresholds: their existence under scrutiny.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it.

1. Relation of different measures of low-density lipoprotein cholesterol to risk of coronary artery disease and death in a meta-regression analysis of large-scale trials of statin therapy.The American journal of cardiology · 2010
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2. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials.BMJ (Clinical research ed.) · 2003
   Pooled it
3. A strategy to reduce cardiovascular disease by more than 80%.BMJ (Clinical research ed.) · 2003 · on this map
   Pooled it
4. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis.BMJ (Clinical research ed.) · 2002
   Pooled it
5. Discordance of low-density lipoprotein (LDL) cholesterol with alternative LDL-related measures and future coronary events.Circulation · 2014
   Trial
6. Effect of plant sterols on the lipid profile of patients with hypercholesterolaemia. Randomised, experimental study.BMC complementary and alternative medicine · 2011
   Trial
7. An international randomised placebo-controlled trial of a four-component combination pill ("polypill") in people with raised cardiovascular risk.PloS one · 2011 · on this map
   Trial
8. Effects of different forms of hazelnuts on blood lipids and α-tocopherol concentrations in mildly hypercholesterolemic individuals.European journal of clinical nutrition · 2011
   Trial
9. The effect of a hypertension self-management intervention on diabetes and cholesterol control.The American journal of medicine · 2009
   Trial
10. Blood folate level needed for fully effective fortification in the prevention of neural tube defects.Archives of disease in childhood · 2025
    Article
11. Polypills in the Management of Cardiovascular Risk-A Perspective.Journal of clinical medicine · 2024 · on this map
    Article
12. Comparing screening based on the NHS Health Check and Polypill Prevention Programmes in the primary prevention of heart attacks and strokes.Journal of medical screening · 2024
    Article
13. Time effect on cardiometabolic risk indicators in patients with bipolar disorder: a longitudinal case-control study.European archives of psychiatry and clinical neuroscience · 2023
    Article
14. Cardiometabolic risk indicators in individuals with bipolar disorders: a replication study.Diabetology & metabolic syndrome · 2023
    Article
15. Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog.BMJ medicine · 2023
    Article
16. Rate of Intraoperative Crystalloid Administration During Thoracic Surgery Is Causal in Reducing Postoperative Hospital Length of Stay.Ochsner journal · 2023
    Article
17. Cost-Effectiveness of Using the Coronary Calcium Score to Guide Therapeutic Decisions in Primary Prevention in the Brazilian Population.Arquivos brasileiros de cardiologia · 2022
    Article
18. Lipoprotein Lipase Inhibitor, Nordihydroguaiaretic Acid, Aggravates Metabolic Phenotypes and Alters HDL Particle Size in the Western Diet-Fed db/db Mice.International journal of molecular sciences · 2019
    Article
19. Polypill: an affordable strategy for cardiovascular disease prevention in low-medium-income countries.Therapeutic advances in cardiovascular disease · 2018
    Review
20. Performance of 4 definitions of childhood elevated blood pressure in predicting subclinical cardiovascular outcomes in adulthood.Journal of clinical hypertension (Greenwich, Conn.) · 2018
    Article

2 more citing papers are in PubMed but not listed here.

Corrections and comments

• Commented on by
  Risk factor thresholds. Threshold is 37 000 pounds sterling per QALY.2002
• Commented on by
  Risk factor thresholds. Hypothesis is dangerous nonsense.2002
• Commented on by
  Risk factor thresholds. Pharmacological treatment should not be determined by age alone.2002

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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