ArticleNucleic acids research2002
Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Overlaps Between CDS Regions of Protein-Coding Genes in the Human Genome: A Case Study on the NR1D1-THRA Gene Pair.Journal of molecular evolution · 2023Article
- Overlapping protein-coding genes in human genome and their coincidental expression in tissues.Scientific reports · 2019Article
- Sense-antisense gene pairs: sequence, transcription, and structure are not conserved between human and mouse.Frontiers in genetics · 2013Article
- Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals.Human genetics · 2012Article
- Overlapping genes in the human and mouse genomes.BMC genomics · 2008Article
- Birth and death of gene overlaps in vertebrates.BMC evolutionary biology · 2007Article
- Overlapping of genes in the human genome.International journal of biomedical science : IJBS · 2007Article
- The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12.BMC genomics · 2003Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overlapping of genes, especially in an anti-parallel fashion, is quite rare in eukaryotic genomes. We have found a rare instance of exon overlapping involving CHRNE and MINK gene loci on chromosome 17 in humans. CHRNE codes for the epsilon subunit of the nicotinic acetylcholine receptor (AChRepsilon) whereas MINK encodes a serine/threonine kinase belonging to the GCK family. To elucidate the evolutionary trail of this gene overlapping event, we examined the genomes of a number of primates and found that mutations in the polyadenylation signal of the CHRNE gene in early hominoids led to the overlap. Upon extending this analysis to genomes of other orders of placental mammals, we observed that the overlapping occurred at least three times independently during the course of mammalian evolution. Because CHRNE and MINK are differentially expressed, the potentially hazardous mutations responsible for the exon overlap seem to have escaped evolutionary pressures by differential temporo-spatial expression of the two genes.
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