ArticleBritish journal of cancer2002
Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus - correlation with proliferation and clinicopathological parameters.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Cadherins, catenins and cell cycle regulators: impact on survival in a Gynecologic Oncology Group phase II endometrial cancer trial.Gynecologic oncology · 2011Trial
- Cyclin-dependent kinase inhibitors in malignant hematopoiesis.Frontiers in oncology · 2022Review
- Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapies.Cell death & disease · 2016Article
- Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.Current molecular medicine · 2016Article
- Cell-cycle protein expression in a population-based study of ovarian and endometrial cancers.Frontiers in oncology · 2015Article
- Subcellular localization of p27 and prostate cancer recurrence: automated digital microscopy analysis of tissue microarrays.Human pathology · 2011Article
- Necrosis related HIF-1alpha expression predicts prognosis in patients with endometrioid endometrial carcinoma.BMC cancer · 2010Article
- The E7 protein from human papillomavirus type 16 enhances keratinocyte migration in an Akt-dependent manner.Oncogene · 2007Article
- High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma.Journal of cancer research and clinical oncology · 2005Article
- Significance of effector protease receptor-1 expression and its relationship with proliferation and apoptotic index in patients with primary advanced gastric adenocarcinoma.World journal of gastroenterology · 2004Article
- p27Kip1 modulates cell migration through the regulation of RhoA activation.Genes & development · 2004Article
- PTEN immunohistochemical expression is suppressed in G1 endometrioid adenocarcinoma of the uterine corpus.Journal of cancer research and clinical oncology · 2004Article
- Significantly decreased P27 expression in endometrial carcinoma compared to complex hyperplasia with atypia (correlation with p53 expression).Pathology oncology research : POR · 2004Article
- Immunohistochemical expression of cyclin E in endometrial adenocarcinoma (endometrioid type) and its clinicopathological significance.Journal of cancer research and clinical oncology · 2003Article
- Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma.Journal of microscopy and ultrastructureArticle
- KRIBB11 Exerts Anticancer Effects on A172 Glioblastoma CellsCancer genomics & proteomicsArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p27 is regarded as a cyclin-dependent kinase inhibitor of the G1-to-S cell cycle progression by suppressing the kinase activity of cyclin/cyclin-dependent kinase complex. This study aimed to investigate p27 expression in the normal endometrium and endometrioid adenocarcinoma of the uterine corpus and the correlation of its expression with cell proliferation and clinicopathological parameters. Tissue samples of 127 endometrioid adenocarcinomas and 15 normal endometria were used in the study. Immunohistochemical staining for detecting p27 and Ki-67 was performed by the labelled streptavidin-biotin method on formalin-fixed and paraffin-embedded tissue samples. The expression was given as the labelling index, which indicates the percentage of positive nuclei. p27 staining was observed in the nuclei of the glandular cells in the functional layer of the secretory phase endometrium, whereas it was negative in those of the proliferative phase. In endometrioid adenocarcinomas, the labelling index of p27 expression paradoxically increased more significantly in the higher histological grades and was correlated with that of Ki-67. The high level of p27 expression was associated with clinicopathological parameters such as FIGO stage, lymph node metastasis, lymphovascular space involvement and myometrial invasion. High p27 expression was linked to higher grades of endometrioid adenocarcinoma, cell proliferation and some clinical prognostic factors. These results indicate that p27 might be an indicator of poor prognosis.
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