ArticleOncogene2002
Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 106 citations in OpenAlex.
- Resistance of E2F4DN to p38Scientific reports · 2026Article
- Paraptosis-A Distinct Pathway to Cell Death.International journal of molecular sciences · 2024Review
- Subcellular distribution of prohibitin 1 in rat liver during liver regeneration and its cellular implication.World journal of hepatology · 2024Article
- Targeting Cell Cycle Facilitates E1A-Independent Adenoviral Replication.Journal of virology · 2023Article
- Cell cycle regulation of the psoriasis associated gene CCHCR1 by transcription factor E2F1.PloS one · 2023Article
- Paraptosis: a unique cell death mode for targeting cancer.Frontiers in pharmacology · 2023Review
- Article
- A Putative Prohibitin-Calcium Nexus inJournal of diabetes research · 2020Review
- Review
- Principal Aspects Regarding the Maintenance of Mammalian Mitochondrial Genome Integrity.International journal of molecular sciences · 2017Review
- β-catenin induces expression of prohibitin gene in acute leukemic cells.Oncology reports · 2017Article
- Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.International journal of molecular sciences · 2016Article
- A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation.Oncotarget · 2015Article
- Multifaceted role of prohibitin in cell survival and apoptosis.Apoptosis : an international journal on programmed cell death · 2015Review
- RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy.Oncotarget · 2015Review
- miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury.Cell death and differentiation · 2015Article
- [The establishment of Raji drug-resistant cell line and analyses of prohibitin and miR-27a expression].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Article
- Characterization of PHB1 and its role in mitochondrial maturation and yolk platelet degradation during development of Artemia embryos.PloS one · 2014Article
- Follicular stage-dependent regulation of apoptosis and steroidogenesis by prohibitin in rat granulosa cells.Journal of ovarian research · 2013Article
- A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.Genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Prohibitin, a potential tumor suppressor, is known to induce growth suppression and repress E2F-mediated transcription. These growth regulatory functions of prohibitin require a physical interaction with the Rb protein. We now find that prohibitin protects cells from apoptosis mediated by camptothecin, a topoisomerase I inhibitor. Camptothecin treatment of Ramos B cells leads to the degradation of Rb protein and phosphorylation of its family members, p107 and p130. This correlates with an increase in the levels of cyclin E as well as the kinase activity associated with it. Inactivation of Rb leads to the dissociation and release of free E2F. We find also that E2F activity is induced upon camptothecin treatment, but this increase is absent in prohibitin overexpressing cells. It thus appears that prohibitin may be inhibiting apoptosis by downregulating E2F activity when Rb family members are inactive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.