ArticleBritish journal of cancer2002
Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Glucose metabolic phenotype of pancreatic cancer.World journal of gastroenterology · 2016Pooled it
- LKB1/STK11 Tumor Suppressor Reduces Angiogenesis by Directly Interacting with VEGFR2 in Tumorigenesis.Biomolecules & therapeutics · 2023Article
- Identification of a Prognostic Signature Composed of GPI, IL22RA1, CCT6A and SPOCK1 for Lung Adenocarcinoma Based on Bioinformatic Analysis of lncRNA-Mediated ceRNA Network and Sample Validation.Frontiers in oncology · 2022Article
- Genetic Signatures of Glucose Homeostasis: Synergistic Interplay With Long-Term Exposure to Cigarette Smoking in Development of Primary Colorectal Cancer Among African American Women.Clinical and translational gastroenterology · 2021Article
- Asparagus Polysaccharide inhibits the Hypoxia-induced migration, invasion and angiogenesis of Hepatocellular Carcinoma Cells partly through regulating HIF1α/VEGF expression via MAPK and PI3K signaling pathway.Journal of Cancer · 2021Article
- Phosphoglycerate Mutase 1 Prevents Neuronal Death from Ischemic Damage by Reducing Neuroinflammation in the Rabbit Spinal Cord.International journal of molecular sciences · 2020Article
- Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis.Clinical & experimental metastasis · 2019Review
- Up-regulation of Key Glycolysis Proteins in Cancer Development.Open life sciences · 2018Article
- Higher autocrine motility factor/glucose-6-phosphate isomerase expression is associated with tumorigenesis and poorer prognosis in gastric cancer.Cancer management and research · 2018Article
- Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors.Frontiers in oncology · 2017Review
- Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs.Frontiers in oncology · 2017Review
- Role of TRPC1 channels in pressure-mediated activation of murine pancreatic stellate cells.European biophysics journal : EBJ · 2016Article
- Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway.Cellular and molecular life sciences : CMLS · 2016Review
- Microfluidics‑based optimization of neuroleukin‑mediated regulation of articular chondrocyte proliferation.Molecular medicine reports · 2016Article
- Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer.Oncotarget · 2015Article
- sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1α signaling pathways.Oncotarget · 2015Article
- Targeting cancer cell metabolism in pancreatic adenocarcinoma.Oncotarget · 2015Review
- Lactate as an insidious metabolite due to the Warburg effect.Molecular biology reports · 2015Review
- Hypoxia-inducible factor 1 and cardiovascular disease.Annual review of physiology · 2014Review
- The role of hypoxia inducible factor-1 in hepatocellular carcinoma.BioMed research international · 2014Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of distant metastases is higher in the tumours with low oxygen pressure than in those with high oxygen pressure. It is well known that hypoxia induces the transcription of various genes involved in angiogenesis and anaerobic metabolism necessary for the growth of tumour cells in vivo, suggesting that hypoxia may also induce the transcription of metastasis-associated genes. We sought to identify the metastasis-associated genes differentially expressed in tumour cells under hypoxic conditions with the use of a DNA microarray system. We found that hypoxia enhanced the expression of autocrine motility factor mRNA in various cancer cells and also enhanced the random motility of pancreatic cancer cells. Autocrine motility factor inhibitors abrogated the increase of motility under hypoxic conditions. In order to explore the roles of hypoxia-inducible factor-1alpha, we established hypoxia-inducible factor-1alpha-transfectants and dominant negative hypoxia-inducible factor-1alpha-transfectants. Transfection with hypoxia-inducible factor-1alpha and dominant-negative hypoxia-inducible factor-1alpha enhanced and suppressed the expression of autocrine motility factor/phosphohexase isomerase/neuroleukin mRNA and the random motility, respectively. These results suggest that hypoxia may promote the metastatic potential of cancer cells through the enhanced autocrine motility factor/phosphohexase isomerase/neuroleukin mRNA expression and that the disruption of the hypoxia-inducible factor-1 pathway may be an effective treatment for metastasis.
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