ArticleProceedings of the National Academy of Sciences of the United States of America2002
Deciphering peripheral nerve myelination by using Schwann cell expression profiling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 146 citations in OpenAlex.
- Article
- The Dance Between Schwann Cells and Macrophages During the Repair of Peripheral Nerve Injury.Neuroscience bulletin · 2025Review
- Pain kept under wraps of myelin sheath.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Article
- TheCancers · 2024Review
- Ets-1 transcription factor regulates glial cell regeneration and function in planarians.Development (Cambridge, England) · 2023Article
- The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration.Molecular medicine (Cambridge, Mass.) · 2023Article
- The transcriptional profile of keloidal Schwann cells.Experimental & molecular medicine · 2022Article
- JUN Regulation of Injury-Induced Enhancers in Schwann Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The Etv1/Er81 transcription factor coordinates myelination-related genes to regulate Schwann cell differentiation and myelination.Annals of translational medicine · 2022Article
- Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in Control of Myelination Identity.Neuroscience bulletin · 2022Article
- An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury.Journal of neuroinflammation · 2022Article
- Placental genomics mediates genetic associations with complex health traits and disease.Nature communications · 2022Article
- Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery.Bioactive materials · 2022Article
- Study of the pathology and the underlying molecular mechanism of tissue injury around hematoma following intracerebral hemorrhage.Molecular medicine reports · 2021Article
- Mesenchymal Stem Cells Derived from Wharton's Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts.Tissue engineering and regenerative medicine · 2021Article
- Bioinformatic analysis of cytokine expression in the proximal and distal nerve stumps after peripheral nerve injury.Neural regeneration research · 2021Article
- Article
- Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease.Frontiers in cell and developmental biology · 2021Review
- Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy.Glia · 2020Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Although mutations in multiple genes are associated with inherited demyelinating neuropathies, the molecular components and pathways crucial for myelination remain largely unknown. To approach this question, we performed genome-wide expression analysis in several paradigms where the status of peripheral nerve myelination is dynamically changing. Anchor gene correlation analysis, a form of microarray analysis that integrates functional information, using correlation-based clustering, with a statistically rigorous test, the Westfall and Young step-down algorithm, was applied to this data set. Biological pathways active in myelination, genes encoding proteins involved in myelin synthesis, and genes whose mutation results in myelination defects were identified. Many known genes and previously uncharacterized ESTs not heretofore associated with myelination were also identified. One of these ESTs, MASR (myelin-associated SUR4 protein), encodes a member of the SUR4 family of fatty acid desaturases, enzymes involved in elongation of very long chain fatty acids. Its specific localization in myelinating Schwann cells indicates a crucial role for MASR in normal myelin lipid synthesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.