Evidence map›Paper›PMID 12084318›Full record

ReviewCurrent urology reports2000

Lower urinary tract physiology and pharmacology.

M E DiSanto, A J Wein, S Chacko

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current urology reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Why do stress and urge incontinence co-occur much more often than expected?International urogynecology journal and pelvic floor dysfunction · 2008
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M E DiSantoDivision of Urology, 3010 Ravdin Courtyard, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. mdisanto@mail.med.upenn.edu
A J Wein
S Chacko
University of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review focuses on what we consider to be the most important findings of the last year relating to the smooth muscle of the lower urogenital system and the different levels of regulation that control its contraction and relaxation. One level is through modulation of the smooth muscle itself or its environment. Recent findings examining myosin isoform composition and collagen content as well as mechanisms that appear to be involved in inducing hyperplasia/hypertrophy of smooth muscle are described. Another method of regulation is via calcium-dependent phosphorylation of the regulatory light chain of myosin, which increases its activity. Interesting results indicating an uncoupling of force from calcium in the bladder are discussed. A third level of regulation is pharmacologic. Thus, the most recent findings related to receptor subtypes, including muscarinic, endothelin, alpha-adrenergic and nicotinic receptors, are presented. In addition, the effects of diabetes, incontinence, and partial bladder outlet obstruction on these modes of contractile regulation are also discussed.

Indexed as

AnimalsFemaleGonadal Steroid HormonesHumansMaleMuscle, SmoothMyosinsNitric Oxide SynthasePressureReceptors, Adrenergic, alphaReceptors, EndothelinReceptors, MuscarinicUrethraUrinary BladderUrinary Bladder Neck ObstructionUrinary IncontinenceGonadal Steroid HormonesMyosinsNitric Oxide SynthaseReceptors, Adrenergic, alphaReceptors, EndothelinReceptors, Muscarinic

Identifiers

PMID12084318
OpenAlexW1969394290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.