ArticleMolecular and cellular biochemistry2002
Sex differences in p-aminohippuric acid transport in rat kidney: role of membrane fluidity and expression of OAT1.
Article in Molecular and cellular biochemistry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Interplay of Breast Cancer Resistance Protein (Bcrp/Abcg2), Sex, and Fed State in Oral Pharmacokinetic Variability of Furosemide in Rats.Pharmaceutics · 2023Article
- Endothelin system expression in the kidney following cisplatin-induced acute kidney injury in male and female mice.Canadian journal of physiology and pharmacology · 2022Article
- A Furosemide Excretion Stress Test Predicts Mortality in Mice After Sepsis and Outperforms the Furosemide Stress Test During Vasopressin Administration.Critical care explorations · 2020Article
- Estrogen receptor α (ERα) indirectly induces transcription of human renal organic anion transporter 1 (OAT1).Physiological reports · 2019Article
- Mycophenolic Acid and Its Metabolites in Kidney Transplant Recipients: A Semimechanistic Enterohepatic Circulation Model to Improve Estimating Exposure.Journal of clinical pharmacology · 2018Article
- Sex differences in transplantation.Transplantation reviews (Orlando, Fla.) · 2017Review
- Sex and the Lab: An Alcohol-Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies.Alcoholism, clinical and experimental research · 2016Review
- Sex differences in cardiovascular drug-induced adverse reactions causing hospital admissions.British journal of clinical pharmacology · 2012Article
- Endocrine and metabolic regulation of renal drug transporters.Journal of biochemical and molecular toxicology · 2012Review
- Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6.PloS one · 2012Article
- Gender related differences in kidney injury induced by mercury.International journal of molecular sciences · 2012Article
- Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacological reviews · 2010Review
- Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- Gender aspects in cardiovascular pharmacology.Journal of cardiovascular translational research · 2009Review
- Characterization of the mechanisms involved in the increased renal elimination of bromosulfophthalein during cholestasis: involvement of Oatp1.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Physiology, structure, and regulation of the cloned organic anion transporters.Xenobiotica; the fate of foreign compounds in biological systems · 2008Review
- Gender differences in kidney function.Pflugers Archiv : European journal of physiology · 2007Review
- Immunocytochemical characterization of the incubated rat renal cortical slices.Pflugers Archiv : European journal of physiology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex differences in the kinetic parameters of p-aminohippuric acid (PAH) transport in brush border (BBMV) and basolateral (BLMV) membrane vesicles from kidney cortex have been observed. Membrane fluidity of BBMV was higher in females as compared with male rats as indicated by anisotropy values (0.1897 +/- 0.0010 vs. 0.2003 +/- 0.0014, p < 0.05, for females and males respectively). Membrane fluidity of BLMV were similar in both sexes. Western blot studies revealed that OAT1 protein in female BLMV was present at only 40% of level found in BLMV from male rats. The lower expression of OAT1 in BLMV in association with the higher BBMV fluidity (which may affect the affinity of PAH transporter in this membrane domain) observed in females may be responsible, at least in part, for the gender difference described in renal PAH secretion.
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