ArticleAmerican journal of human genetics2002
Genetic isolates in East Asia: a study of linkage disequilibrium in the X chromosome.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.PloS one · 2020Article
- Divergence of East Asians and Europeans estimated using male- and female-specific genetic markers.Genome biology and evolution · 2014Article
- A functional polymorphism in the epidermal growth factor gene predicts hepatocellular carcinoma risk in Japanese hepatitis C patients.OncoTargets and therapy · 2013Article
- Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population.Journal of medical genetics · 2012Article
- X-linked insertion/deletion polymorphisms: forensic applications of a 33-markers panel.International journal of legal medicine · 2010Article
- Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.Genetic epidemiology · 2010Article
- Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.The Journal of clinical endocrinology and metabolism · 2009Article
- The value of some Corsican sub-populations for genetic association studies.BMC medical genetics · 2008Article
- Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians.Human genetics · 2008Article
- Increased level of linkage disequilibrium in rural compared with urban communities: a factor to consider in association-study design.American journal of human genetics · 2005Article
- X-chromosome as a marker for population history: linkage disequilibrium and haplotype study in Eurasian populations.European journal of human genetics : EJHG · 2005Article
- Evaluation of microsatellite markers in association studies: a search for an immune-related susceptibility gene in sarcoidosis.Immunogenetics · 2005Article
- Striking differentiation of sub-populations within a genetically homogeneous isolate (Ogliastra) in Sardinia as revealed by mtDNA analysis.Human genetics · 2003Article
- Two-step association analyses of the chromosome 18p11.2 region in schizophrenia detect a locus encompassing C18orf1.Molecular psychiatry · 2003Article
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10 authors.
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Abstract
The background linkage disequilibrium (LD) in genetic isolates is of great interest in human genetics. Although many empirical studies have evaluated the background LD in European isolates, such as the Finnish and Sardinians, few data from other regions, such as Asia, have been reported. To evaluate the extent of background LD in East Asian genetic isolates, we analyzed the X chromosome in the Japanese population and in four Mongolian populations (Khalkh, Khoton, Uriankhai, and Zakhchin), the demographic histories of which are quite different from one another. Fisher's exact test revealed that the Japanese and Khalkh, which are the expanded populations, had the same or a relatively higher level of LD than did the Finnish, European American, and Sardinian populations. In contrast, the Khoton, Uriankhai, and Zakhchin populations, which have kept their population size constant, had a higher background LD. These results were consistent with previous genetic anthropological studies in European isolates and indicate that the Japanese and Khalkh populations could be utilized in the fine mapping of both complex and monogenic diseases, whereas the Khoton, Uriankhai, and Zakhchin populations could play an important role in the initial mapping of complex disease genes.
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