ArticleOncogene2002
Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 84 citations in OpenAlex.
- MST1/Hippo promoter gene methylation predicts poor survival in patients with malignant pleural mesothelioma in the IFCT-GFPC-0701 MAPS Phase 3 trial.British journal of cancer · 2019Trial
- Investigating Aging and DNA Methylation: A Path to Improving Health Span?The Yale journal of biology and medicine · 2025Review
- The role of viruses in cancer development versus cancer therapy: An oncological perspective.Cancer medicine · 2023Review
- Immunotherapy, the promise for present and future of malignant pleural mesothelioma (MPM) treatment.Therapeutic advances in medical oncology · 2021Review
- SV40 and human mesothelioma.Translational lung cancer research · 2020Review
- A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control.Cell communication and signaling : CCS · 2018Article
- DNA Tumor Virus Regulation of Host DNA Methylation and Its Implications for Immune Evasion and Oncogenesis.Viruses · 2018Review
- Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.Oncology letters · 2016Article
- Viral epigenetics.Methods in molecular biology (Clifton, N.J.) · 2015Review
- Review
- Desmoplastic malignant mesothelioma originating from the peritoneum.Medical oncology (Northwood, London, England) · 2012Article
- Article
- Genomic events associated with progression of pleural malignant mesothelioma.International journal of cancer · 2009Article
- Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors.Journal of cancer research and clinical oncology · 2009Review
- Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma.Carcinogenesis · 2008Article
- Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors.Journal of carcinogenesis · 2008Article
- The Ras-association domain family (RASSF) members and their role in human tumourigenesis.Biochimica et biophysica acta · 2007Review
- Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour.British journal of cancer · 2005Article
- Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection.Oncogene · 2005Article
- MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias.Leukemia · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Mesotheliomas are tumors arising from mesothelial cells and are associated with asbestos exposure and approximately 50% contain simian virus 40 (SV40) DNA sequences. SV40 infection of human mesothelial cells (HM) causes early cellular immortalization and late transformation. Aberrant methylation is a major mech-anism for loss of function of tumor suppressor genes (TSGs). We recently reported that of seven genes frequently methylated in epithelial tumors, only RASSF1A gene was frequently methylated in mesotheliomas, and its methylation was correlated with loss of RASSF1A expression and the presence of SV40. We studied whether SV40 infection of normal HM induces aberrant methylation of the genes previously studied in mesotheliomas. Of six infected foci examined at early passages (passages 8-30) there was no methylation of the seven genes examined. Of two foci examined at late passages (passages 51-86) after the appearance of morphological changes suggestive of transformation, methylation and loss of expression of RASSF1A was detected. Sequencing of the CpG dense region around the transcription start site and semi-quantitative real-time methylation specific PCR (MSP) assay for RASSF1A methylation demonstrated progressive methylation during late passages. Exposure to the demethylating agent 5-aza-2'-deoxycytidine restored RASSF1A expression, while exposure to the histone deacetylation inhibitor trichostatin A had no effect. These data, together with our previous findings, support a causal relationship between SV40 infection, progressive RASSF1A methylation and its silencing, and the pathogenesis of mesothelioma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.