Trial reportThe pharmacogenomics journal2002
Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease.
Trial report in The pharmacogenomics journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- Association between polymorphisms in the beta2-adrenergic receptor gene with myocardial infarction and ischaemic stroke in women.Thrombosis and haemostasis · 2009Trial
- Distinct network patterns emerge from Cartesian and XOR epistasis models: a comparative network science analysis.BioData mining · 2024Article
- Distinct Network Patterns Emerge from Cartesian and XOR Epistasis Models: A Comparative Network Science Analysis.Research square · 2024Article
- Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis.BioData mining · 2024Article
- Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes.International journal of environmental research and public health · 2021Review
- Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population.Human genomics · 2016Article
- Analysis of gene-gene interactions.Current protocols in human genetics · 2011Article
- Bayesian epistasis association mapping via SNP imputation.Biostatistics (Oxford, England) · 2011Article
- Association between polymorphisms in the beta2-adrenoceptor gene and migraine in women.Headache · 2009Article
- Detecting disease-associated genotype patterns.BMC bioinformatics · 2009Article
- Variable selection in logistic regression for detecting SNP-SNP interactions: the rheumatoid arthritis example.European journal of human genetics : EJHG · 2008Article
- The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases.BMC genetics · 2006Article
- Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease.Genes and immunity · 2005Article
- Trick or treat: the effect of placebo on the power of pharmacogenetic association studies.Human genomics · 2005Article
- Haplotype analysis of the beta2 adrenergic receptor gene and risk of myocardial infarction in humans.Genetics · 2005Article
- TP53 haplotype-based analysis and incidence of post-angioplasty restenosis.Human genetics · 2004Article
- A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies.American journal of human genetics · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
The complexity of recognizing the potential contribution of a number of possible predictors of complex disorders is increasingly challenging with the application of large-scale single nucleotide polymorphism (SNP) typing. In the search for putative genetic factors predisposing to coronary artery restenosis following balloon angioplasty, we determined genotypes for 94 SNPs representing 62 candidate genes, in a prospectively assembled cohort of 342 cases and 437 controls. Using a customized coupled-logistic regression procedure accounting for both additive and interactive effects, we identified seven SNPs in seven genes that, together, showed a statistically significant association with restenosis incidence (P <0.0001), accounting for 11.6% of overall variance observed. Among them are candidate genes for cardiovascular pathophysiology (apolipoprotein-species and NOS), inflammatory response (TNF receptor and CD14), and cell-cycle control (p53 and p53-associated protein). Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.