ArticleMolecular psychiatry2002
Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.
Article in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glutamatergic abnormalities of the thalamus in schizophrenia: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2008Pooled it
- Analysis of Nucleotide Variations in Human G-Quadruplex Forming Regions Associated with Disease States.Genes · 2023Article
- Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia.Journal of personalized medicine · 2021Article
- Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism.Translational psychiatry · 2017Article
- Glutamate neurocircuitry: theoretical underpinnings in schizophrenia.Frontiers in pharmacology · 2012Article
- Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.Translational psychiatry · 2011Article
- Association between the G1001C polymorphism in the GRIN1 gene promoter and schizophrenia in the Iranian population.Journal of molecular neuroscience : MN · 2009Article
- Interindividual variability of methadone response: impact of genetic polymorphism.Molecular diagnosis & therapy · 2008Review
- Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder.Genes, brain, and behavior · 2007Article
- N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives.Psychopharmacology · 2005Review
- Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study.Psychopharmacology · 2004Article
- Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region.Molecular psychiatry · 2004Article
- Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD.Molecular psychiatry · 2004Article
- Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives.Clinical pharmacokinetics · 2004Review
- The molecular genetics of schizophrenia: new findings promise new insights.Molecular psychiatry · 2004Review
- Linkage and association studies of schizophrenia.Current psychiatry reports · 2003Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The glutamatergic system is the major excitatory neurotransmitter system in the CNS. Glutamate receptors, and in particular N-methyl-D-aspartate (NMDA) receptors, have been proposed as mediators of many common neuropsychiatric phenotypes including cognition, psychosis, and degeneration. We have reconstructed the genomic structure of all five genes encoding NMDA receptors in silico. We screened each for sequence variation and estimated the allele frequencies of all detected SNPs in pooled samples of 184 UK Caucasian schizophrenics and 184 UK Caucasian blood donor controls. Only a single non-synonymous polymorphism was found indicating extreme selection pressure. The rarity of non-synonymous changes suggests that such variants are unlikely to make a common contribution to common phenotypes. We found a further 26 polymorphisms within exonic or adjacent intronic sequences. The minor alleles of most of these have a relatively high frequency (63% above 0.2). These SNPs will therefore be suitable for studying neuropsychiatric phenotypes that are putatively related to NMDA dysfunction. Pooled analysis provided no support for association between any of the GRIN genes and schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.