ArticleOncogene2002
c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Bcl-xL is important for the antiapoptotic activity of Gfi1 and is upregulated by Gfi1 through hemgn.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- MYC and the control of DNA replication.Cold Spring Harbor perspectives in medicine · 2014Review
- c-MYC-induced genomic instability.Cold Spring Harbor perspectives in medicine · 2014Review
- Three-dimensional Nuclear Telomere Organization in Multiple Myeloma.Translational oncology · 2013Article
- A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.Molecular and cellular biology · 2009Article
- Global rank-invariant set normalization (GRSN) to reduce systematic distortions in microarray data.BMC bioinformatics · 2008Article
- Article
- c-Myc-dependent formation of Robertsonian translocation chromosomes in mouse cells.Neoplasia (New York, N.Y.) · 2007Article
- Article
- Deregulation of common genes by c-Myc and its direct target, MT-MC1.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1.Oncogene · 2005Article
- c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Article
- Coordinate increase of telomerase activity and c-Myc expression in Helicobacter pylori-associated gastric diseases.World journal of gastroenterology · 2004Article
- The three-dimensional organization of telomeres in the nucleus of mammalian cells.BMC biology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of c-Myc in tumors is usually associated with cell proliferation and increased susceptibility to apoptosis. Concomitantly, c-Myc contributes to tumorigenesis by its ability to destabilize the cellular genome. Here, we examined whether c-Myc induces genomic instability and apoptosis in c-Myc-activated cells. Wild-type Myc (wt-Myc) and two mutated Myc myc box II proteins (mt-Myc) were overexpressed in IL3-dependent murine Ba/F3 cells. As expected, wt-Myc triggered apoptosis in absence of IL3. Standard karyotyping, spectral karyotyping, and fluorescent in situ hybridization (FISH) were performed before and after c-Myc activation. Structural and numerical genomic instability was detected 48 h after wt-Myc activation and included gene amplification, the formation of extrachromosomal elements (EEs), chromosome breakage, deletions, increased aneuploidy, and polyploidization. Interestingly, some cells simultaneously displayed genomic instability and apoptosis. Both wt- and mt-Myc proteins were equally potent promoters of genomic instability. However, only wt-Myc simultaneously induced genomic instability and apoptosis. Mt-Myc proteins failed to induce apoptosis, thereby generating a strong imbalance towards the survival of genomically unstable cells.
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Registered trials
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