ArticleOncogene2002
Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 89 citations in OpenAlex.
- WT1 and PRAME RNA-loaded dendritic cell vaccine as maintenance therapy in de novo AML after intensive induction chemotherapy.Leukemia · 2023Article
- Article
- DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.Journal of the American Society of Nephrology : JASN · 2019Article
- Cloning, characterization and function analysis of DAX1 in Chinese loach (Paramisgurnus dabryanus).Genetica · 2018Article
- Identification of WT1 as determinant of heptatocellular carcinoma and its inhibition by Chinese herbal medicineOncotarget · 2017Article
- Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models.Physiological genomics · 2017Review
- Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).The Biochemical journal · 2014Review
- Wt1 in the kidney--a tale in mouse models.Pediatric nephrology (Berlin, Germany) · 2014Review
- Mammalian kidney development: principles, progress, and projections.Cold Spring Harbor perspectives in biology · 2012Review
- A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression.Developmental cell · 2011Article
- Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation.The Journal of clinical investigation · 2011Article
- AHR regulates WT1 genetic programming during murine nephrogenesis.Molecular medicine (Cambridge, Mass.) · 2011Article
- Article
- Comparative analysis of the mammalian WNT4 promoter.BMC genomics · 2009Article
- An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.Nucleic acids research · 2009Article
- No evidence for WT1 involvement in a beta-catenin-independent activation of the Wnt signaling pathway in pituitary adenomas.Endocrine pathology · 2009Article
- WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression.Molecular cancer research : MCR · 2008Article
- Wnt signaling in kidney development and disease.Organogenesis · 2008Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wilms' tumour suppressor gene, WT1, encodes multiple nuclear protein isoforms, all containing four C-terminal zinc finger motifs. WT1 proteins can both activate and repress putative target genes in vitro, although the in vivo relevance of these putative target genes is often unverified. WT1 mutations can result in Wilms' tumour and the Denys-Drash Syndrome (DDS) of infantile nephropathy, XY pseudohermaphroditism and predisposition to Wilms' tumour. We have established stable transfectants of the mouse mesonephric cell line, M15, which express WT1 harbouring a common DDS point mutation (R394W). A comparison of the expression profiles of M15 and transfectant C2A was performed using Nylon-based arrays. Very few genes showed differential expression. However Wnt-4, a member of the Wnt gene family of secreted glycoproteins, was downregulated in C2A and other similar clones. Doxycycline induction of WT1-A or WT1-D expression in HEK293 stable transfectants also elicited an elevation in Wnt4 expression. Wnt4 is critical for the mesenchyme-to-epithelial transition during kidney development, making it an attractive putative WT1 target. We have mapped human Wnt-4 gene to chromosome 1p35-36, a region of frequent LOH in WT, have characterized the genomic structure of the human Wnt-4 gene and isolated 9 kb of immediate promoter. While several potential WT1 binding sites exist within this promoter, reporter analysis does not strongly support the direct regulation of Wnt4 by WT1. We propose that Wnt-4 regulation by WT1 occurs at a more distant promoter or enhancer site, or is indirect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.