ArticleProceedings of the National Academy of Sciences of the United States of America2002
Apparent role of traveling metabolic waves in oxidant release by living neutrophils.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 75 citations in OpenAlex.
- Migratory responses in enucleated cells: The forces driving the locomotion movement of unicellular organisms.PNAS nexus · 2025Article
- Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.Frontiers in genetics · 2021Review
- Imaging enzymes at work: metabolic mapping by enzyme histochemistry.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Review
- Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis.Arthritis and rheumatism · 2009Article
- Phagocytic leukocytes and reactive oxygen species.Histochemistry and cell biology · 2009Review
- Reactive oxygen species in phagocytic leukocytes.Histochemistry and cell biology · 2008Review
- Neutrophils: the forgotten cell in JIA disease pathogenesis.Pediatric rheumatology online journal · 2007Article
- Fronts and pulses in an enzymatic reaction catalyzed by glucose oxidase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Differential clearance and immune responses to tick cell-derived versus macrophage culture-derived Ehrlichia chaffeensis in mice.Infection and immunity · 2007Article
- Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Electron and proton transport by NADPH oxidases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Ion channel clustering enhances weak electric field detection by neutrophils: apparent roles of SKF96365-sensitive cation channels and myeloperoxidase trafficking in cellular responses.European biophysics journal : EBJ · 2005Article
- Voltage- and NADPH-dependence of electron currents generated by the phagocytic NADPH oxidase.The Biochemical journal · 2005Article
- Fluorescence spectroscopic detection of mitochondrial flavoprotein redox oscillations and transient reduction of the NADPH oxidase-associated flavoprotein in leukocytes.European biophysics journal : EBJ · 2004Article
- Concerted simulations reveal how peroxidase compound III formation results in cellular oscillations.Biophysical journal · 2003Article
- Signal sequence within Fc gamma RIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.The Journal of clinical investigation · 2002Article
- Shooting from the hip: spatial control of signal release by intracellular waves.Proceedings of the National Academy of Sciences of the United States of America · 2002Review
Corrections and comments
- Retraction · 2010-06-01Concerns/Issues about Data · · BA 06/12/17
- Commented on by
- Retracted
- RetractedRetraction.2010
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell metabolism self-organizes into two types of dissipative structures: chemical oscillations and traveling metabolic waves. In the present study we test the hypothesis that traveling NAD(P)H waves within neutrophils are associated spatially and temporally with the release of reactive oxygen metabolites (ROMs). Using high-speed optical microscopy and taking advantage of the autofluorescence of NAD(P)H, we have observed the propagation of NAD(P)H waves within cells. When NAD(P)H waves reach the lamellipodium of morphologically polarized neutrophils, a diffusing plume of superoxide is released as evidenced by the conversion of hydroethidine in the extracellular environment to ethidium bromide. Parallel results were obtained by using high-speed emission microspectrophotometry. These experiments indicate that the spatial and temporal properties of NAD(P)H waves are transformed into ROM pulses in the extracellular environment. Propagating NAD(P)H waves allow neutrophils to specifically deliver substrate to the lamellipodium at high concentrations, thus facilitating the local and periodic release of ROMs in the direction of cell movement and/or a target.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.