ArticleJournal of neurology, neurosurgery, and psychiatry2002
Inflammation and neuropathic attacks in hereditary brachial plexus neuropathy.
Article in Journal of neurology, neurosurgery, and psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis).The Cochrane database of systematic reviews · 2009Pooled it
- Review
- [Diagnostics and treatment of hourglass-like nerve constrictions and torsions in neuralgic amyotrophy].Der Nervenarzt · 2023Article
- Hereditary Neuralgic Amyotrophy with a Lesion Distal to the Brachial Plexus on Magnetic Resonance Imaging.Internal medicine (Tokyo, Japan) · 2023Article
- Identification of a rare SEPT9 variant in a family with autosomal dominant Charcot-Marie-Tooth disease.BMC medical genetics · 2020Article
- Herpes zoster increased risk of neuralgic amyotrophy: a retrospective, population-based matched cohort study.Journal of neurovirology · 2019Article
- Hereditary neuralgic amyotrophy in childhood caused by duplication within the SEPT9 gene: A family study.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Recurrent Brachial Neuritis Attacks in Presentation of B-Cell Lymphoma.Mayo Clinic proceedings. Innovations, quality & outcomes · 2018Article
- Inflammatory Neuropathy of the Lumbosacral Plexus following Periacetabular Osteotomy.Case reports in orthopedics · 2016Article
- Neuralgic amyotrophy and hepatitis E virus infection.Neurology · 2014Article
- Inherited neuropathies: clinical overview and update.Muscle & nerve · 2013Review
- Brachial plexopathy.Annals of Indian Academy of Neurology · 2013Article
- Recurrent vocal fold paralysis and parsonage-turner syndrome.Case reports in otolaryngology · 2013Article
- Surgical and postpartum hereditary brachial plexus attacks and prophylactic immunotherapy.Muscle & nerve · 2013Article
- Clinical and pathophysiological concepts of neuralgic amyotrophy.Nature reviews. Neurology · 2011Review
- Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy.Human molecular genetics · 2009Article
- SEPT9 mutations and a conserved 17q25 sequence in sporadic and hereditary brachial plexus neuropathy.Archives of neurology · 2009Article
- The neuralgic amyotrophy consultation.Journal of neurology · 2007Review
- Clinical utility of peripheral nerve biopsy.Current neurology and neuroscience reports · 2005Review
- Clinical Mimickers of Amyotrophic Lateral Sclerosis-Conditions We Cannot Afford to Miss.Annals of Indian Academy of NeurologyReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo study the role of mechanical, infectious, and inflammatory factors inducing neuropathic attacks in hereditary brachial plexus neuropathy (HBPN), an autosomal dominant disorder characterised by attacks of pain and weakness, atrophy, and sensory alterations of the shoulder girdle and upper limb muscles.
methodsFour patients from separate kindreds with HBPN were evaluated. Upper extremity nerve biopsies were obtained during attacks from a person of each kindred. In situ hybridisation for common viruses in nerve tissue and genetic testing for a hereditary tendency to pressure palsies (HNPP; tomaculous neuropathy) were undertaken. Two patients treated with intravenous methyl prednisolone had serial clinical and electrophysiological examinations. One patient was followed prospectively through pregnancy and during the development of a stereotypic attack after elective caesarean delivery.
resultsUpper extremity nerve biopsies in two patients showed prominent perivascular inflammatory infiltrates with vessel wall disruption. Nerve in situ hybridisation for viruses was negative. There were no tomaculous nerve changes. In two patients intravenous methyl prednisolone ameliorated symptoms (largely pain), but with tapering of steroid dose, signs and symptoms worsened. Elective caesarean delivery did not prevent a typical postpartum attack.
conclusionsInflammation, probably immune, appears pathogenic for some if not all attacks of HBPN. Immune modulation may be useful in preventing or reducing the neuropathic attacks, although controlled trials are needed to establish efficacy, as correction of the mutant gene is still not possible. The genes involved in immune regulation may be candidates for causing HBPN disorders.
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Registered trials
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