ArticlePlant molecular biology2002
Cell cycle-dependent and lysine residue-specific dynamic changes of histone H4 acetylation in barley.
Article in Plant molecular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Epigenetic regulation of centromere function.Cellular and molecular life sciences : CMLS · 2020Review
- Article
- Live imaging of H3K9 acetylation in plant cells.Scientific reports · 2017Article
- Article
- Histone acetyltransferases in plant development and plasticity.Current genomics · 2014Article
- Article
- Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize.BMC plant biology · 2010Article
- Recent advances in rice genome and chromosome structure research by fluorescence in situ hybridization (FISH).Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
- Histone modifications associated with both A and B chromosomes of maize.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Transcription and histone modifications in the recombination-free region spanning a rice centromere.The Plant cell · 2005Article
- Dynamic histone acetylation of late embryonic genes during seed germination.Plant molecular biology · 2005Article
- Identification of a novel plant MAR DNA binding protein localized on chromosomal surfaces.Plant molecular biology · 2004Article
- Centromere-specific acetylation of histone H4 in barley detected through three-dimensional microscopy.Plant molecular biology · 2003Article
- Roles of dynamic and reversible histone acetylation in plant development and polyploidy.Biochimica et biophysica actaReview
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone acetylation affects chromatin conformation and regulates various cellular functions, such as transcription and cell cycle progression. Although mitosis dependent transcriptional silencing and large-scale chromatin structural changes are well established, acetylation of histone H4 during the mitosis is poorly understood in plants. Here, the dynamics of acetylation of histone H4 in defined genome regions has been examined in the fixed barley cells throughout the mitosis by three-dimensional microscopy. Patterns of strong acetylation of the two lysine residues K5 and K16 of histone H4 in the barley genomes were found to be different. In interphase nuclei, H4 acetylated at K 16 was associated with the gene-rich, telomere-associated hemispheres, whereas K5 acetylation was detected in centromeric regions where the heterochromatin is distributed. Regions of strong K5 acetylation changed dynamically as the cell cycle proceeded. At prometaphase, centromeric acetylation at K5 decreased suddenly, with accompanying rapid increases of acetylation in the nucleolar organizing regions (NORs). Reverse changes occurred at telophase. On the other hand, the strongly acetylated regions of the K16 showed changes compatible with transcriptional activities and chromosome condensation throughout the cell cycle. Telomeric acetylation at K16 was detected throughout the cell cycle, although it was reduced at metaphase which corresponds to the most condensed stage of the chromosomes. It is concluded that dynamic changes in H4 acetylation occur in a lysine residue-, stage-, and region-specific manner and that they correlate with changes in the chromosome structure through the cell cycle.
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