ArticleJournal of epidemiology and community health2002
Alcohol consumption and the incidence of type II diabetes.
Article in Journal of epidemiology and community health, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Alcohol as a risk factor for type 2 diabetes: A systematic review and meta-analysis.Diabetes care · 2009Pooled it
- Alcohol consumption and type 2 diabetes Meta-analysis of epidemiological studies indicates a U-shaped relationship.Diabetologia · 2005Pooled it
- Alcohol consumption and diabetes risk in the Diabetes Prevention Program.The American journal of clinical nutrition · 2009Trial
- Health effects associated with alcohol consumption: a Burden of Proof study.Nature health · 2026Article
- Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling.Cancers · 2025Review
- Metabolic dysfunction and alcohol-related liver disease (MetALD): Position statement by an expert panel on alcohol-related liver disease.Journal of hepatology · 2025Review
- Investigating whether smoking and alcohol behaviours influence risk of type 2 diabetes using a Mendelian randomisation study.Scientific reports · 2025Article
- Mediating factors associated with alcohol intake and periodontal condition.Frontiers in oral health · 2025Article
- The association between alcohol consumption and blood lipids in Chinese children and adolescent: findings from the China Health and Nutrition Survey.BMC pediatrics · 2024Article
- Integration of dietary nutrition and TRIB3 action into diabetes mellitus.Nutrition reviews · 2024Review
- The Six Pillars of Lifestyle Medicine in Managing Noncommunicable Diseases - The Gaps in Current Guidelines.Arquivos brasileiros de cardiologia · 2024Article
- Low Risk for Developing Diabetes Among the Offspring of Individuals With Exceptional Longevity and Their Spouses.Frontiers in clinical diabetes and healthcare · 2022Article
- Moderate Consumption of Beer and Its Effects on Cardiovascular and Metabolic Health: An Updated Review of Recent Scientific Evidence.Nutrients · 2021Review
- Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse Model of Metabolic Syndrome.International journal of molecular sciences · 2021Article
- Alcohol-induced impaired insulin secretion in a Japanese population: 5-year follow up in the Gifu Diabetes Study.Journal of diabetes investigation · 2020Article
- Alcohol Consumption, Diabetes Risk, and Cardiovascular Disease Within Diabetes.Current diabetes reports · 2017Review
- Association between insulin and executive functioning in alcohol dependence: a pilot study.Neuropsychiatric disease and treatment · 2015Article
- Average volume of alcohol consumed, drinking patterns, and metabolic syndrome in older Korean adults.Journal of epidemiology · 2013Article
- Integrating information on substance use disorders into electronic health record systems.Journal of substance abuse treatment · 2012Article
- Alcoholism and diabetes mellitus.Diabetes & metabolism journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study examines the relation between alcohol and type II diabetes and the possible mediating effects of HDL-cholesterol and serum insulin.
methodsProspective study of 5221 men aged 40-59 years with no history of coronary heart disease, diabetes, or stroke drawn from general practices in 18 British towns.
resultsDuring the mean follow up of 16.8 years there were 198 incident cases of type II diabetes. Occasional drinkers were the reference group. A non-linear relation was seen between alcohol intake and age adjusted risk of diabetes, with risk lowest in light and moderate drinkers and highest in heavy drinkers (quadratic trend p=0.03). Further adjustment for body mass index decreased risk in heavy drinkers. After additional adjustment for physical activity, smoking, and (undiagnosed) pre-existing coronary heart disease, only moderate drinkers showed significantly lower risk than occasional drinkers (RR=0.66 95% CI 0.44 to 0.99). Alcohol intake was inversely associated with serum insulin and positively associated with HDL-cholesterol. Adjustment for these factors reduced the "protective" effect in moderate drinkers (adjusted RR=0.73 95% CI 0.48 to 1.10) but the quadratic trend remained significant (p=0.02).
conclusionThere is a non-linear relation between alcohol intake and the risk of type II diabetes. Serum insulin and HDL-cholesterol explained a small amount (20%) of the reduction in risk of type II diabetes associated with moderate drinking. The adverse effect of heavy drinking seemed to be partially mediated through its effect on body weight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.