ArticleBMC immunology2002
Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11.
Article in BMC immunology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Mast cells: a novel therapeutic avenue for cardiovascular diseases?Cardiovascular research · 2024Review
- Exploring Mast Cell-CD8 T Cell Interactions in Inflammatory Skin Diseases.International journal of molecular sciences · 2023Review
- Mast Cells and Interleukins.International journal of molecular sciences · 2022Review
- Wheat Bran Extract Regulates Mast Cell-Mediated Allergic Responses In Vitro and In Vivo.Molecules (Basel, Switzerland) · 2020Article
- Mast cells as sources of cytokines, chemokines, and growth factors.Immunological reviews · 2018Review
- Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance.The Journal of allergy and clinical immunology · 2018Article
- Efficacy of Omalizumab in a Patient with Angioedema Clinically Resembling a Hereditary Angioedema.Annals of dermatology · 2016Article
- Healing effects of omalizumab in a patient with cholinergic urticaria associated severe dyspeptic complaints.Chinese medical journal · 2015Article
- Article
- Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata.PloS one · 2014Article
- CADM1 is expressed as multiple alternatively spliced functional and dysfunctional isoforms in human mast cells.Molecular immunology · 2013Article
- Using the allergic immune system to target cancer: activity of IgE antibodies specific for human CD20 and MUC1.Cancer immunology, immunotherapy : CII · 2012Article
- IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models.Journal of leukocyte biology · 2008Article
- Article
- Article
- Cell-type specific gene expression profiles of leukocytes in human peripheral blood.BMC genomics · 2006Article
- Selective inhibition of the Fc epsilon RI-induced de novo synthesis of mediators by an inhibitory receptor.The EMBO journal · 2006Article
- Article
- Mast cells enhance T cell activation: Importance of mast cell-derived TNF.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn asthma and other allergic disorders, the activation of mast cells by IgE and antigen induces the cells to release histamine and other mediators of inflammation, as well as to produce certain cytokines and chemokines. To search for new mast cell products, we used complementary DNA microarrays to analyze gene expression in human umbilical cord blood-derived mast cells stimulated via the high-affinity IgE receptor (Fc(epsilon)RI).
resultsOne to two hours after Fc(epsilon)RI-dependent stimulation, more than 2,400 genes (about half of which are of unknown function) exhibited 2-200 fold changes in expression. The transcriptional program included changes in the expression of IL-11 and at least 30 other cytokines and chemokines. Human mast cells secreted 130-529 pg of IL-11/106 cells by 6 h after stimulation with anti-IgE.
conclusionOur initial analysis of the transcriptional program induced in in vitro-derived human mast cells stimulated via the Fc(epsilon)RI has identified many products that heretofore have not been associated with this cell type, but which may significantly influence mast cell function in IgE-associated host responses. We also have demonstrated that mast cells stimulated via the Fc(epsilon)RI can secrete IL-11. Based on the previously reported biological effects of IL-11, our results suggest that production of IL-11 may represent one link between IgE-dependent mast cell activation in subjects with allergic asthma and the development of a spectrum of structural changes in the airways of these individuals; such changes, collectively termed "airway remodeling," can constitute an important long term consequence of asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.