ArticleThe Annals of thoracic surgery2002
High-grade esophageal dysplasia: long-term survival and quality of life after esophagectomy.
Article in The Annals of thoracic surgery, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Serum autoantibodies in the early detection of esophageal cancer: a systematic review.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Systematic review reveals limitations of studies evaluating health-related quality of life after potentially curative treatment for esophageal cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2013Pooled it
- The risk of lymph-node metastases in patients with high-grade dysplasia or intramucosal carcinoma in Barrett's esophagus: a systematic review.The American journal of gastroenterology · 2012Pooled it
- Systematic review of health-related quality of life after esophagectomy for esophageal cancer.World journal of gastroenterology · 2011Pooled it
- Treatment for Barrett's oesophagus.The Cochrane database of systematic reviews · 2010Pooled it
- Preemptive surgery for premalignant foregut lesions.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Pooled it
- Quality of life following radiofrequency ablation of dysplastic Barrett's esophagus.Endoscopy · 2010Trial
- Correlation of histology with biomarker status after photodynamic therapy in Barrett esophagus.Cancer · 2008Trial
- Revisional surgery for delayed gastric conduit emptying after esophagectomy: the RESTORANT project.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026Article
- Delayed gastric conduit emptying after esophagectomy: attempt at a clinically relevant classification.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025Article
- Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes?Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024Article
- Functional syndromes and symptom-orientated aftercare after esophagectomy.Langenbeck's archives of surgery · 2021Review
- Effect of multidisciplinary team care on survival of oesophageal cancer patients: a retrospective nationwide cohort study.Scientific reports · 2021Article
- Long-Term Quality of Life Following Endoscopic Therapy Compared to Esophagectomy for Neoplastic Barrett's Esophagus.Digestive diseases and sciences · 2021Article
- Cell-free microRNA-1246 in different body fluids as a diagnostic biomarker for esophageal squamous cell carcinoma.PloS one · 2021Article
- Usefulness of serum miR-1246/miR-106b ratio in patients with esophageal squamous cell carcinoma.Oncology letters · 2020Article
- Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis.Cancer science · 2020Article
- Autoantibodies against tumor-associated antigens combined with microRNAs in detecting esophageal squamous cell carcinoma.Cancer medicine · 2020Observational
- Phase IB Study of Induction Chemotherapy With XELOX, Followed by Radiation Therapy, Carboplatin, and Everolimus in Patients With Locally Advanced Esophageal Cancer.American journal of clinical oncology · 2019Article
- Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway.World journal of gastroenterology · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophagectomy for high-grade dysplasia in Barrett's esophagus has been advocated. Although long-term survival data exist, little is known about functional outcome and quality of life in this particular subset of patients.
methodsThe records of all patients who underwent esophageal resection for high-grade dysplasia from June 1991 through July 1997 were reviewed. Long-term functional outcome and quality of life were assessed using a two-part written survey.
resultsThere were 54 patients (48 men, 6 women). Median age was 64 years (range, 36 to 83 years). Ivor Lewis esophagogastrectomy was performed in 34 patients (63%), transhiatal esophagectomy in 10 (18%), extended esophagectomy in 8 (15%), and other in 2 (4%). Invasive carcinoma was found in 19 patients (35%). Five patients (9%) were stage 0, 7 (13%) stage I, 3 (6%) stage IIA, 1 (2%) stage IIB, and 3 patients (6%) stage III. There was one operative death (1.8%). Complications occurred in 31 patients (57%). Median hospitalization was 13 days (range, 11 to 44 days). Follow-up was complete in all patients and ranged from 6 months to 9 years (median, 63 months). Overall 5-year survival was 86% and did not differ significantly from a population matched for age and gender. Five-year survival for patients with only high-grade dysplasia was 96% and 68% for patients with cancer (p = 0.017). Quality of life was measured by the Medical Outcomes Study 36-Item Short-Form Health Survey. For patients with only high-grade dysplasia, the role-physical and role-emotional scores were better than for the control population (p < 0.03). For patients with cancer, the health perception score was worse than for the control population (p < 0.03). Scores measuring physical-function, social function, mental health, bodily pain, and energy/fatigue were similar.
conclusionsAlthough perioperative morbidity is significant, surgical resection of high-grade dysplasia in Barrett's esophagus provides excellent long-term survival with acceptable function and quality of life.
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