ArticleMolecular and cellular biology2002
The class II transactivator requires brahma-related gene 1 to activate transcription of major histocompatibility complex class II genes.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?Protein science : a publication of the Protein Society · 2024Article
- Chemical and genetic control of IFNγ-induced MHCII expression.EMBO reports · 2018Article
- Beyond Mutations: Additional Mechanisms and Implications of SWI/SNF Complex Inactivation.Frontiers in oncology · 2014Review
- The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators.Frontiers in microbiology · 2013Article
- Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO.Immunology letters · 2012Article
- Gamma interferon modulates myogenesis through the major histocompatibility complex class II transactivator, CIITA.Molecular and cellular biology · 2011Article
- The unique transcriptional activation domain of nuclear factor-I-X3 is critical to specifically induce marker gene expression in astrocytes.The Journal of biological chemistry · 2011Article
- Expression regulation of major histocompatibility complex class I and class II encoding genes.Frontiers in immunology · 2011Article
- An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.Molecular and cellular biochemistry · 2010Article
- Nucleosome eviction from MHC class II promoters controls positioning of the transcription start site.Nucleic acids research · 2009Article
- Chromatin remodeling complex in Treg function.International immunopharmacology · 2009Review
- The SWI/SNF complex and cancer.Oncogene · 2009Review
- New dimensions of CIITA.Nature immunology · 2008Article
- Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator.The Journal of biological chemistry · 2008Article
- The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.Journal of molecular biology · 2007Article
- ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.Molecular immunology · 2007Article
- Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes.Oncogene · 2004Article
- CIITA regulates transcription onset viaSer5-phosphorylation of RNA Pol II.The EMBO journal · 2003Article
- Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The class II transactivator (CIITA) is the key regulator of major histocompatibility complex (MHC) class II gene transcription. We demonstrate here that CIITA requires the ATPase subunit of an hSWI/SNF complex, brahma-related gene 1 (BRG-1), to activate transcription. When introduced into a cell line lacking BRG-1, CIITA was unable to activate cellular MHC class II genes. Reexpression of the wild-type but not an ATP-binding-deficient BRG-1 protein in this cell line restored the ability of CIITA to transactivate transcription of MHC class II genes. Interestingly, when the activity of CIITA was assayed in the BRG-1-deficient cell line by using a plasmid-based reporter assay, BRG-1 was not required for transcriptional activation, suggesting that the chromatin structure on the plasmid is such that BRG-1 is not necessary. Coimmunoprecipitation experiments were performed to determine if BRG-1 and CIITA proteins associate with each other in cells. We found that the two proteins coimmunoprecipitate and that amino acids 1 to 140 of CIITA are sufficient for binding. Taken together, these data suggest that BRG-1 and, very likely, an hSWI/SNF complex are required for transcription of MHC class II genes. The complex is likely recruited to MHC class II promoters, at least in part, by interaction with CIITA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.