ArticleProceedings of the National Academy of Sciences of the United States of America2002
Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast.Cell cycle (Georgetown, Tex.) · 2020Review
- Pheromone-induced morphogenesis and gradient tracking are dependent on the MAPK Fus3 binding to Gα.Molecular biology of the cell · 2015Article
- Tunable signal processing through a kinase control cycle: the IKK signaling node.Biophysical journal · 2013Article
- Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans.PloS one · 2012Article
- Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Systematic analysis of essential genes reveals important regulators of G protein signaling.Molecular cell · 2010Article
- Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways.Eukaryotic cell · 2009Article
- Signaling threshold regulation by the Ras effector IMP.The Journal of biological chemistry · 2009Review
- Degradation of activated protein kinases by ubiquitination.Annual review of biochemistry · 2009Review
- Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.Molecular and cellular biology · 2009Article
- Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis.Current biology : CB · 2008Article
- Mathematical and computational analysis of adaptation via feedback inhibition in signal transduction pathways.Biophysical journal · 2007Article
- Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.Biochimica et biophysica acta · 2007Review
- Mechanisms regulating the protein kinases of Saccharomyces cerevisiae.Eukaryotic cell · 2007Review
- Dynamic studies of scaffold-dependent mating pathway in yeast.Biophysical journal · 2006Article
- Pheromone-induced degradation of Ste12 contributes to signal attenuation and the specificity of developmental fate.Eukaryotic cell · 2006Article
- Application of Petri net based analysis techniques to signal transduction pathways.BMC bioinformatics · 2006Article
- Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade.Biophysical journal · 2006Article
- Polymerization of the SAM domain of MAPKKK Ste11 from the budding yeast: implications for efficient signaling through the MAPK cascades.Protein science : a publication of the Protein Society · 2005Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ste11 is the mitogen-activated protein kinase (MAPK) kinase kinase in the MAPK cascades that mediate mating, high osmolarity glycerol, and filamentous growth responses in Saccharomyces cerevisiae. We show stimulation of the mating pathway by pheromone promotes an accelerated turnover of Ste11 through a MAPK feedback and ubiquitin-dependent mechanism. This degradation is pathway specific, because Ste11 is stable during activation of the high osmolarity glycerol pathway. Because the steady-state amount of Ste11 does not change significantly during pheromone induction, we infer that maintenance of MAPK activation involves repeated cycles in which naive Ste11 is activated and then targeted for degradation. This model predicts that elimination of active Ste11 would rapidly curtail MAPK activation upon attenuation of the upstream signal. This prediction is confirmed by the finding that blocking ubiquitin-dependent Ste11 degradation during pheromone induction abolishes the characteristic attenuation profile for MAPK activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.