ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Growth cone collapse induced by semaphorin 3A requires 12/15-lipoxygenase.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
- Semaphorins and Their Role in Neuropathic Pain.Life (Basel, Switzerland) · 2026Review
- Expanding the genetic and clinical landscapes of hereditary spastic paraplegia (HSP): a cohort study of 103 families.Orphanet journal of rare diseases · 2026Article
- Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.Nature communications · 2023Article
- Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.bioRxiv : the preprint server for biology · 2023Article
- Regulation of the E/I-balance by the neural matrisome.Frontiers in molecular neuroscience · 2023Review
- Identification and Functional Characterization of a Novel Variant in theInternational journal of endocrinology · 2022Article
- Inhibition of Cytosolic Phospholipase AJournal of neurotrauma · 2021Article
- Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.Advances in experimental medicine and biology · 2019Article
- Review
- Mammalian lipoxygenases and their biological relevance.Biochimica et biophysica acta · 2015Review
- Damage of hippocampal neurons in rats with chronic alcoholism.Neural regeneration research · 2014Article
- Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections.Science signaling · 2014Article
- Semaphorin 3A inactivation suppresses ischemia-reperfusion-induced inflammation and acute kidney injury.American journal of physiology. Renal physiology · 2014Article
- Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis.Free radical biology & medicine · 2014Review
- Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons.PloS one · 2013Article
- Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance.PloS one · 2013Article
- Group IVA phospholipase A₂ is necessary for growth cone repulsion and collapse.Journal of neurochemistry · 2012Article
- Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly.Cytoskeleton (Hoboken, N.J.) · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Detection of a repellent factor, such as a semaphorin (Sema), causes localized collapse of the growth cone and directs the neurite away from the repellent. Growth cone collapse results from concomitant cytoskeletal rearrangements and detachment of adhesion sites from the extracellular matrix, via mostly unknown signaling mechanisms. In cultures of dorsal root ganglion neurons, we found that Sema3A treatment stimulates the synthesis of the eicosanoid, 12(S)-hydroxyeicosatetraenoic acid (HETE), whereas Sema3A-induced growth cone collapse is prevented when 12(S)-HETE synthesis is blocked with an inhibitor of 12/15-lipoxygenase (LO). Exogenously applied product of 12/15-LO, 12(S)-HETE, mimics Sema3A-induced collapse. As observed by interference reflection and confocal microscopy, 12(S)-HETE causes the loss of growth cone adhesion sites. The adhesion site effect seems partially independent of the actin cytoskeleton because growth cones treated with Sema3A and 12/15-LO inhibitor remain spread despite actin cytoskeleton loss. These studies demonstrate that 12/15-LO activity is a necessary step in Sema3A collapse signaling in growth cones and suggest a mechanism for its action.
Indexed as
Identifiers
12077190PMC6757732W2139770516What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.