ArticleGut2002
Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 69 citations in OpenAlex.
- Higher Glucose and Insulin Levels Are Associated with Risk of Liver Cancer and Chronic Liver Disease Mortality among Men without a History of Diabetes.Cancer prevention research (Philadelphia, Pa.) · 2016Trial
- Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus.Journal of gastroenterology · 2008Trial
- Impact of biomarkers on disease survival and progression in patients treated with octreotide for advanced hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2006Trial
- Insulin resistance: mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Review
- Associations between serum glucose, insulin, insulin resistance and the risk of incident primary liver cancer or chronic liver disease mortality: a nested case-control study.British journal of cancer · 2023Article
- Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women.The American journal of gastroenterology · 2019Article
- Nonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma.Clinics in liver disease · 2015Review
- Effect of pioglitazone on outcome following curative treatment for hepatocellular carcinoma in patients with hepatitis C virus infection: A prospective study.Molecular and clinical oncology · 2015Article
- Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension.Journal of gastroenterology · 2014Article
- Interaction between hepatitis C virus and metabolic factors.World journal of gastroenterology · 2014Review
- Prospective evaluation of type 2 diabetes mellitus on the risk of primary liver cancer in Chinese men and women.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver cirrhosis: a comparative investigation using human autopsy specimens.Journal of gastroenterology · 2013Article
- Liver and diabetes. A vicious circle.Hepatology research : the official journal of the Japan Society of Hepatology · 2013Article
- Resection of nonalcoholic steatohepatitis-associated hepatocellular carcinoma: a Western experience.International journal of surgical oncology · 2012Article
- Chronic hepatitis c genotype-4 infection: role of insulin resistance in hepatocellular carcinoma.Virology journal · 2011Article
- Importance of hepatitis C virus-associated insulin resistance: therapeutic strategies for insulin sensitization.World journal of gastroenterology · 2010Review
- Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case.Clinical journal of gastroenterology · 2008Article
- Association of digestive organ disease with metabolic syndrome: role of adipocytokine and its molecular mechanisms.Clinical journal of gastroenterology · 2008Article
- Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism.
aimsTo investigate whether impaired glucose metabolism affects the growth rate of the tumour. PATIENTS AND
methodsTumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 patients with single small HCC (diameter <30 mm). DT was compared with plasma insulin and glucose concentrations following the oral glucose tolerance test (OGTT). The effect of continuous infusion of octreotide (a somatostatin analogue 200 microg/day) for three months on DT in five cases was assessed.
resultsThe 60 patients were divided into two groups because the median DT was 140 days: rapid growth group (DT <or=140 days, n=30) and slow growth group (DT >140 days, n=30). Fasting plasma insulin concentration and area under the plasma insulin curve (AUC(ins)) of the OGTT (10.4 (6.2) microU/ml and 262 (152) microU/ml/h, respectively; mean (SD)) in the rapid growth group were significantly higher than those in the slow growth group (7.6 (4.3) and 146 (140), respectively) (p=0.041 and p=0.0006, respectively). In contrast, fasting plasma glucose concentration and area under the plasma glucose curve (AUC(gluc)) in the rapid growth group were significantly lower than those in the slow growth group (p=0.0003 and p=0.0012, respectively). Univariate and multivariate analyses of logistic regression models demonstrated that AUC(ins) was a significant factor contributing to the growth rate of HCC (p=0.001 and p=0.016, respectively). AUC(ins) significantly decreased after octreotide treatment (p<0.02) but AUC(gluc) did not significantly change. DT after treatment increased in three of the five patients and could not be calculated in the remaining two patients because of no change in the diameter of the tumour.
conclusionsThese data suggest that postprandial hyperinsulinaemia is associated with accelerated HCC growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.