ArticleGut2002
Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.
Article in Gut, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Human intestinal B cells in inflammatory diseases.Nature reviews. Gastroenterology & hepatology · 2023Review
- NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections.Communications biology · 2022Article
- Reduced CD27Frontiers in immunology · 2019Article
- High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry.Mucosal immunology · 2016Article
- Article
- Alteration of DSS-mediated immune cell redistribution in murine colitis by oral colostral immunoglobulin.BMC immunology · 2013Article
- [Linear IgA disease with ocular involvement associated with ulcerative colitis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2010Article
- Article
- Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells.The Journal of molecular diagnostics : JMD · 2006Article
- CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis.Genes and immunity · 2004Article
- Article
- IGHV1, IGHV5 and IGHV7 subgroup genes in the rhesus macaque.Immunogenetics · 2003Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by peripheral antigen which homed to the colonic mucosa. The clonal distribution of IgG secreting cells and isotype switched variants in UC is not known.
aimsTo investigate the clonal distribution of mucosal IgG in UC and to search for related IgG and IgA secreting cells in normal and diseased mucosa and blood in UC. To investigate characteristics which may discriminate between the mucosal and peripheral repertoire in the normal mucosa and in UC. PATIENTS: Blood and normal and diseased mucosa from two patients with UC were studied.
methodsImmunoglobulin gene analysis and clone specific polymerase chain reaction were used to study the clonal distribution and characteristics of IgG and related IgA in the mucosa and blood of patients with UC.
resultsThe IgG response in the mucosa of UC patients included widespread clones of cells that were present in both the diseased mucosa and blood but that were scarce in normal mucosa. Clonally related IgA class switch variants, all IgA1, were detected but also only in the diseased mucosa and blood. This suggests that these clones home preferentially to the diseased mucosa. We showed that J(H)1 usage was characteristic of the peripheral repertoire, and that examples of J(H)1 usage were observed in mucosal IgG in UC.
conclusionsOverall, these data are consistent with a model of UC in which a peripheral response is expressed and expanded in the colonic mucosa.
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Registered trials
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