Evidence map›Paper›PMID 12076182›Full record

ReviewDrugs2002

Treatment of heroin (diamorphine) addiction: current approaches and future prospects.

Gerardo Gonzalez, Alison Oliveto, Thomas R Kosten

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drugs, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gerardo GonzalezDepartment of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA. Geraldo.Gonzales-Haddad@yale.edu
Alison Oliveto
Thomas R Kosten
VA Connecticut Healthcare System · USYale University · US

Funding

GABAERGIC &GLUTAMATERGIC AGENTS--COCAINE USE IN METHADONE MAINTENANCEP50DA012762 · NIDA · YALE UNIVERSITY · PI KOSTEN, THOMAS RICHARD · 1999 to 2003
$3.8M
Pharmacotherapy for opioid and cocaine dependenceR01DA005626 · NIDA · YALE UNIVERSITY · PI ROUNSAVILLE, BRUCE · 1988 to 2005
$2.3M
COMORBIDITY IN COCAINE AND OPIOID PHARMACOTHERAPYK05DA000454 · NIDA · YALE UNIVERSITY · PI KOSTEN, THOMAS RICHARD · 2000 to 2010
$1.3M
Comorbid Disorders in Treatment of Opiate DependenceK23DA014331 · NIDA · YALE UNIVERSITY · PI GONZALEZ, GERARDO · 2001 to 2005
$686k
SPECT AND MICRODIALYSIS MEASUREMENT OF COCAINE ABUSEP50DA004060 · NIDA · YALE UNIVERSITY · PI MCCANCE, ELINORE · 1986 to 1999
–
NIDA NIH HHS 1K23DA14331-01NIDA NIH HHS K05-DA00454NIDA NIH HHS P50-DA04060NIDA NIH HHS P50-DA12762NIDA NIH HHS R01-DA05626
6 · The paper itself

Abstract

New pharmacological treatments for heroin (diamorphine) addiction include drugs that reduce opiate withdrawal symptoms and agents that are given during the maintenance phase of treatment. A variety of different types of pharmacological agents (opioid agonists, partial opioid agonists, opioid antagonists and alpha(2)-adrenoreceptor agonists) are reviewed and the evidence of their use during managed withdrawal and maintenance are presented. Experimental approaches attempting to reduce the time of opiate withdrawal and to accelerate the transition to abstinence are being developed. The combination tablet of buprenorphine and naloxone that is to be introduced for office-based maintenance is currently undergoing intense evaluation in the US. This new approach may facilitate the expansion of treatment while reducing the potential for medication diversion and intravenous use.

Indexed as

Adrenergic alpha-2 Receptor AgonistsHeroin DependenceHumansNarcotic AntagonistsReceptors, OpioidAdrenergic alpha-2 Receptor AgonistsNarcotic AntagonistsReceptors, Opioid

Identifiers

PMID12076182
OpenAlexW1986942666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.