ArticleProceedings of the National Academy of Sciences of the United States of America2002
A cytosine methyltransferase homologue is essential for repeat-induced point mutation in Neurospora crassa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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129 citing papers in PubMed, 244 citations in OpenAlex.
- Interspecies hybridization as a route of accessory chromosome origin in fungal pathogens.mBio · 2026Article
- Centromeres are hotspots of cytosine methylation epimutations in a filamentous fungus.bioRxiv : the preprint server for biology · 2026Article
- A genomic perspective on fungal diversity and evolution.Nature reviews. Microbiology · 2025Review
- A reference metagenome sequence of the lichen Cladonia rangiformis.BMC biology · 2025Article
- Phylogenomic signatures of repeat-induced point mutations across the fungal kingdom.PLoS biology · 2025Article
- Harnessing Genomics ofPlants (Basel, Switzerland) · 2025Article
- Tandem repeat-induced sexual silencing: A Rid-dependent RNAi mechanism for fungal genome defense via translational repression.Science advances · 2025Article
- How and when organisms edit their own genomes.Nature genetics · 2025Review
- Starship giant transposons dominate plastic genomic regions in a fungal plant pathogen and drive virulence evolution.Nature communications · 2025Article
- Methylation of mycovirus DNA is mediated by the RNAi machinery in vegetative hyphae of Fusarium graminearum.Nucleic acids research · 2025Article
- RID is required for both repeat-induced point mutation and nucleation of a novel transitional heterochromatic state for euchromatic repeats.Nucleic acids research · 2025Article
- DNA cytosine methyltransferases differentially regulate genome-wide hypermutation and interhomolog recombination in Trichoderma reesei meiosis.Nucleic acids research · 2024Article
- Genomic and Pathogenic Characterization ofGenes · 2024Article
- Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment ineLife · 2024Article
- Sexual stage-specific A-to-I mRNA editing is mediated by tRNA-editing enzymes in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment inbioRxiv : the preprint server for biology · 2024Article
- Recent reactivation of a pathogenicity-associated transposable element is associated with major chromosomal rearrangements in a fungal wheat pathogen.Nucleic acids research · 2024Article
- Article
- Nuclear genome organization in fungi: from gene folding to Rabl chromosomes.FEMS microbiology reviews · 2023Article
- Forest health in the Anthropocene: the emergence of a novel tree disease is associated with poplar cultivation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
69 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During sexual development, Neurospora crassa inactivates genes in duplicated DNA segments by a hypermutation process, repeat-induced point mutation (RIP). RIP introduces C:G to T:A transition mutations and creates targets for subsequent DNA methylation in vegetative tissue. The mechanism of RIP and its relationship to DNA methylation are not fully understood. Mutations in DIM-2, a DNA methyltransferase (DMT) responsible for all known cytosine methylation in Neurospora, does not prevent RIP. We used RIP to disrupt a second putative DMT gene in the Neurospora genome and tested mutants for defects in DNA methylation and RIP. No effect on DNA methylation was detected in the tissues that could be assayed, but the mutants showed recessive defects in RIP. Duplications of the am and mtr genes were completely stable in crosses homozygous for the mutated potential DMT gene, which we call rid (RIP defective). The same duplications were inactivated normally in heterozygous crosses. Disruption of the rid gene did not noticeably affect fertility, growth, or development. In contrast, crosses homozygous for a mutation in a related gene in Ascobolus immersus, masc1, reportedly fail to develop and heterozygous crosses reduce methylation induced premeiotically [Malagnac, F., Wendel, B., Goyon, C., Faugeron, G., Zickler, D., et al. (1997) Cell 91, 281-290]. We isolated homologues of rid from Neurospora tetrasperma and Neurospora intermedia to identify conserved regions. Homologues possess all motifs characteristic of eukaryotic DMTs and have large distinctive C- and N-terminal domains.
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