ArticleGenetics2002
A method for estimating the mutation, gene conversion and recombination parameters in small multigene families.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 48 citations in OpenAlex.
- Multi-dimensional diffusion process of allele frequencies in population genetics.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2021Review
- Population Genetics of the Highly PolymorphicGenes · 2019Article
- The Role of Gene Conversion between Transposable Elements in Rewiring Regulatory Networks.Genome biology and evolution · 2019Review
- Effect of Collapsed Duplications on Diversity Estimates: What to Expect.Genome biology and evolution · 2018Article
- Interlocus gene conversion explains at least 2.7% of single nucleotide variants in human segmental duplications.BMC genomics · 2015Article
- Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario.G3 (Bethesda, Md.) · 2014Article
- Evolution of low-light adapted peripheral light-harvesting complexes in strains of Rhodopseudomonas palustris.Photosynthesis research · 2013Article
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- Hard selective sweep and ectopic gene conversion in a gene cluster affording environmental adaptation.PLoS genetics · 2013Article
- Great majority of recombination events in Arabidopsis are gene conversion events.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The coalescent with selection on copy number variants.Genetics · 2012Article
- Article
- Organization and evolution of hsp70 clusters strikingly differ in two species of Stratiomyidae (Diptera) inhabiting thermally contrasting environments.BMC evolutionary biology · 2011Article
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- Gene conversion in angiosperm genomes with an emphasis on genes duplicated by polyploidization.Genes · 2011Article
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- Population genetic models of duplicated genes.Genetica · 2009Review
- Duplication and gene conversion in the Drosophila melanogaster genome.PLoS genetics · 2008Article
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Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A simple two-locus gene conversion model is considered to investigate the amounts of DNA variation and linkage disequilibrium in small multigene families. The exact solutions for the expectations and variances of the amounts of variation within and between two loci are obtained. It is shown that gene conversion increases the amount of variation within each locus and decreases the amount of variation between two loci. The expectation and variance of the amount of linkage disequilibrium are also obtained. Gene conversion generates positive linkage disequilibrium and the degree of linkage disequilibrium decreases as the recombination rate is increased. Using the theoretical results, a method for estimating the mutation, gene conversion, and recombination parameters is developed and applied to the data of the Amy multigene family in Drosophila melanogaster. The gene conversion rate is estimated to be approximately 60-165 times higher than the mutation rate for synonymous sites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.