ArticleGenetics2002
Genetic linkage analysis of the lesser grain borer Rhyzopertha dominica identifies two loci that confer high-level resistance to the fumigant phosphine.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 98 citations in OpenAlex.
- Chromosome-level genome assembly and annotation of the lesser grain borer, Rhyzopertha dominica (Fabricius) (Coleoptera: Bostrycidae).Scientific data · 2026Article
- Comparative Efficacy of Carbonyl Sulfide Against Phosphine-Resistant and Phosphine-Susceptible Strains of the Rice WeevilInsects · 2026Article
- Multiple mutations in Dihydrolipoamide dehydrogenase gene in phosphine resistant Rhyzopertha Dominica populations from India.Molecular biology reports · 2025Article
- Geographic Distribution of Phosphine Resistance and Frequency of Resistance Genes in Two Species of Grain Beetles,Insects · 2025Article
- Comparison of phenotypic and genotypic frequency of phosphine resistance in select field populations of Tribolium castaneum from India.Molecular biology reports · 2023Article
- Pesticidal Toxicity of Phosphine and Its Interaction with Other Pest Control Treatments.Current issues in molecular biology · 2023Review
- Differential Activities of Antioxidant Enzymes, Superoxide Dismutase, Peroxidase, and Catalase vis-à-vis Phosphine Resistance in Field Populations of Lesser Grain Borer (Antioxidants (Basel, Switzerland) · 2023Article
- The Genome ofGenes · 2022Article
- Molecular genotypic diversity of populations of brinjal shoot and fruit borer, Leucinodes orbonalis and development of SCAR marker for pesticide resistance.Molecular biology reports · 2021Article
- Variant Linkage Analysis UsingGenetics · 2018Article
- Genetic Conservation of Phosphine Resistance in the Rice Weevil Sitophilus oryzae (L.).The Journal of heredity · 2016Article
- Phosphine resistance in India is characterised by a dihydrolipoamide dehydrogenase variant that is otherwise unobserved in eukaryotes.Heredity · 2015Article
- Diagnostic molecular markers for phosphine resistance in U.S. populations of Tribolium castaneum and Rhyzopertha dominica.PloS one · 2015Article
- Inheritance and characterization of strong resistance to phosphine in Sitophilus oryzae (L.).PloS one · 2015Article
- Rapid genome wide mapping of phosphine resistance loci by a simple regional averaging analysis in the red flour beetle, Tribolium castaneum.BMC genomics · 2013Article
- Article
- The rph2 gene is responsible for high level resistance to phosphine in independent field strains of Rhyzopertha dominica.PloS one · 2012Article
- The rph1 gene is a common contributor to the evolution of phosphine resistance in independent field isolates of Rhyzopertha dominica.PloS one · 2012Article
- Mechanisms of phosphine toxicity.Journal of toxicology · 2011Article
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High levels of inheritable resistance to phosphine in Rhyzopertha dominica have recently been detected in Australia and in an effort to isolate the genes responsible for resistance we have used random amplified DNA fingerprinting (RAF) to produce a genetic linkage map of R. dominica. The map consists of 94 dominant DNA markers with an average distance between markers of 4.6 cM and defines nine linkage groups with a total recombination distance of 390.1 cM. We have identified two loci that are responsible for high-level resistance. One provides approximately 50x resistance to phosphine while the other provides 12.5x resistance and in combination, the two genes act synergistically to provide a resistance level 250x greater than that of fully susceptible beetles. The haploid genome size has been determined to be 4.76 x 10(8) bp, resulting in an average physical distance of 1.2 Mbp per map unit. No recombination has been observed between either of the two resistance loci and their adjacent DNA markers in a population of 44 fully resistant F5 individuals, which indicates that the genes are likely to reside within 0.91 cM (1.1 Mbp) of the DNA markers.
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