ArticleGenetics2002
Ectopic expression of the Drosophila Cdk1 inhibitory kinases, Wee1 and Myt1, interferes with the second mitotic wave and disrupts pattern formation during eye development.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic Progression.Journal of developmental biology · 2026Review
- Repurposing a Cyclin-Dependent Kinase 1 (CDK1) Mitotic Regulatory Network to Complete Terminal Differentiation in Lens Fiber Cells.Investigative ophthalmology & visual science · 2023Article
- Genomic insights into evolution and control of Wohlfahrtia magnifica, a widely distributed myiasis-causing fly of warm-blooded vertebrates.Molecular ecology resources · 2022Article
- Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.eLife · 2019Article
- Time varying causal network reconstruction of a mouse cell cycle.BMC bioinformatics · 2019Article
- Distinct gene-selective roles for a network of core promoter factors inBiology open · 2019Article
- The matrix protein Tiggrin regulates plasmatocyte maturation inDevelopment (Cambridge, England) · 2017Article
- Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes.Molecular biology of the cell · 2016Article
- A novel fizzy/Cdc20-dependent mechanism suppresses necrosis in neural stem cells.Development (Cambridge, England) · 2014Article
- Article
- JNK signaling is needed to tolerate chromosomal instability.Cell cycle (Georgetown, Tex.) · 2014Article
- Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2.Journal of cell science · 2013Article
- Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors.Development (Cambridge, England) · 2012Article
- Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- microRNAs regulate human embryonic stem cell division.Cell cycle (Georgetown, Tex.) · 2009Article
- Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development.Genetics · 2008Article
- Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells.Developmental biology · 2007Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wee1 kinases catalyze inhibitory phosphorylation of the mitotic regulator Cdk1, preventing mitosis during S phase and delaying it in response to DNA damage or developmental signals during G2. Unlike yeast, metazoans have two distinct Wee1-like kinases, a nuclear protein (Wee1) and a cytoplasmic protein (Myt1). We have isolated the genes encoding Drosophila Wee1 and Myt1 and are using genetic approaches to dissect their functions during normal development. Overexpression of Dwee1 or Dmyt1 during eye development generates a rough adult eye phenotype. The phenotype can be modified by altering the gene dosage of known regulators of the G2/M transition, suggesting that we could use these transgenic strains in modifier screens to identify potential regulators of Wee1 and Myt1. To confirm this idea, we tested a collection of deletions for loci that can modify the eye overexpression phenotypes and identified several loci as dominant modifiers. Mutations affecting the Delta/Notch signaling pathway strongly enhance a GMR-Dmyt1 eye phenotype but do not affect a GMR-Dwee1 eye phenotype, suggesting that Myt1 is potentially a downstream target for Notch activity during eye development. We also observed interactions with p53, which suggest that Wee1 and Myt1 activity can block apoptosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.