ArticleGenetics2002
rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
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- Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation.Neuroscience bulletin · 2019Article
- Autism Spectrum Disorder-Related Syndromes: Modeling withInternational journal of molecular sciences · 2019Review
- The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein GScientific reports · 2017Article
- Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster.Behavior genetics · 2017Article
- Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.Disease models & mechanisms · 2016Article
- Controlled microfluidics to examine growth-factor induced migration of neural progenitors in the Drosophila visual system.Journal of neuroscience methods · 2016Article
- Article
- Neuron membrane trafficking and protein kinases involved in autism and ADHD.International journal of molecular sciences · 2015Review
- Drosophila mutants of the autism candidate gene neurobeachin (rugose) exhibit neuro-developmental disorders, aberrant synaptic properties, altered locomotion, and impaired adult social behavior and activity patterns.Journal of neurogenetics · 2015Article
- Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders.Molecular neurobiology · 2013Review
- Drosophila rugose is a functional homolog of mammalian Neurobeachin and affects synaptic architecture, brain morphology, and associative learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster.PloS one · 2012Article
- Dendritic spine formation and synaptic function require neurobeachin.Nature communications · 2011Article
- The lens in focus: a comparison of lens development in Drosophila and vertebrates.Molecular genetics and genomics : MGG · 2011Review
- Genetic disruptions of Drosophila Pavlovian learning leave extinction learning intact.Genes, brain, and behavior · 2010Article
- Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.The Journal of physiology · 2009Article
- Crosstalk of Notch with p53 and p63 in cancer growth control.Nature reviews. Cancer · 2009Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the developing Drosophila eye, cell fate determination and pattern formation are directed by cell-cell interactions mediated by signal transduction cascades. Mutations at the rugose locus (rg) result in a rough eye phenotype due to a disorganized retina and aberrant cone cell differentiation, which leads to reduction or complete loss of cone cells. The cone cell phenotype is sensitive to the level of rugose gene function. Molecular analyses show that rugose encodes a Drosophila A kinase anchor protein (DAKAP 550). Genetic interaction studies show that rugose interacts with the components of the EGFR- and Notch-mediated signaling pathways. Our results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.