ArticleGenetics2002
Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental pathology in adult C. elegans.PLoS genetics · 2025Article
- Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy.Clinical science (London, England : 1979) · 2022Article
- DNA repair, recombination, and damage signaling.Genetics · 2022Review
- Review
- Mutational signatures are jointly shaped by DNA damage and repair.Nature communications · 2020Article
- Multigenerational Regulation of theAnnual review of genetics · 2019Review
- Mutational signatures of DNA mismatch repair deficiency inGenome research · 2018Article
- JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress.Scientific reports · 2018Article
- Rapid Increase in frequency of gene copy-number variants during experimental evolution in Caenorhabditis elegans.BMC genomics · 2015Article
- Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.Genome research · 2014Article
- Evolution of gene structural complexity: an alternative-splicing-based model accounts for intron-containing retrogenes.Plant physiology · 2014Article
- DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals.Cell death and differentiation · 2013Article
- The million mutation project: a new approach to genetics in Caenorhabditis elegans.Genome research · 2013Article
- Nucleotide Excision Repair in Caenorhabditis elegans.Molecular biology international · 2011Article
- Cancer models in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2008Review
- Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.Nucleic acids research · 2008Article
- Article
- Aging and the germ line: where mortality and immortality meet.Stem cell reviews · 2007Review
- Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans.Genome biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mismatch-repair-deficient mutants were initially recognized as mutation-prone derivatives of bacteria, and later mismatch repair deficiency was found to predispose humans to colon cancers (HNPCC). We generated mismatch-repair-deficient Caenorhabditis elegans by deleting the msh-6 gene and analyzed the fidelity of transmission of genetic information to subsequent generations. msh-6-defective animals show an elevated level of spontaneous mutants in both the male and female germline; also repeated DNA tracts are unstable. To monitor DNA repeat instability in somatic tissue, we developed a sensitive system, making use of heat-shock promoter-driven lacZ transgenes, but with a repeat that puts this reporter gene out of frame. In genetic msh-6-deficient animals lacZ+ patches are observed as a result of somatic repeat instability. RNA interference by feeding wild-type animals dsRNA homologous to msh-2 or msh-6 also resulted in somatic DNA instability, as well as in germline mutagenesis, indicating that one can use C. elegans as a model system to discover genes involved in maintaining DNA stability by large-scale RNAi screens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.