ArticleThe Biochemical journal2002
Ferritin binds to light chain of human H-kininogen and inhibits kallikrein-mediated bradykinin release.
Article in The Biochemical journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Association of iron metabolism with disease severity in acute Puumala hantavirus infection.BMC nephrology · 2025Article
- Ferritin in Acute Myeloid Leukemia: Not Only a Marker of Inflammation and Iron Overload, but Also a Regulator of Cellular Iron Metabolism, Signaling and Communication.International journal of molecular sciences · 2025Review
- RNA Interference Analysis Reveals the Positive Regulatory Role of Ferritin in Testis Development in the Oriental River Prawn,Frontiers in physiology · 2022Article
- Iron homeostasis is altered in response to hypoxia and hypothermic preconditioning in brain glial cellsTurkish journal of medical sciences · 2020Article
- Interactions of ferritin with scavenger receptor class A members.The Journal of biological chemistry · 2020Article
- Differential processing of high-molecular-weight kininogen during normal pregnancy.Rapid communications in mass spectrometry : RCM · 2020Article
- Serum Ferritin Predicts Neither Organ Dysfunction Nor Mortality in Pediatric Sepsis Due to Tropical Infections.Frontiers in pediatrics · 2020Article
- Increased serum ferritin and interleukin-18 levels in children with dengue.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Emerging and Dynamic Biomedical Uses of Ferritin.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Review
- Hyperferritinaemia in dengue virus infected patients is associated with immune activation and coagulation disturbances.PLoS neglected tropical diseases · 2014Article
- The high-molecular-weight kininogen domain 5 is an intrinsically unstructured protein and its interaction with ferritin is metal mediated.Protein science : a publication of the Protein Society · 2014Article
- The presence of heat-labile factors interfering with binding analysis of fibrinogen with ferritin in horse plasma.Acta veterinaria Scandinavica · 2013Article
- Article
- Serum ferritin: Past, present and future.Biochimica et biophysica acta · 2010Review
- Ferritin for the clinician.Blood reviews · 2009Review
- Regulatory effects of ferritin on angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ferritin is an iron-storage protein that exists in both intracellular and extracellular compartments. We have previously identified H-kininogen (high-molecular-weight kininogen) as a ferritin-binding protein [Torti and Torti (1998) J. Biol. Chem. 273, 13630-13635]. H-Kininogen is a precursor of the potent pro-inflammatory peptide bradykinin, which is released from H-kininogen following cleavage of H-kininogen by the serine protease kallikrein. In this report, we demonstrate that binding of ferritin to H-kininogen occurs via the modified light chain of H-kininogen, and that ferritin binds preferentially to activated H-kininogen. We further demonstrate that binding of ferritin to H-kininogen retards the proteolytic cleavage of H-kininogen by kallikrein and its subsequent release of bradykinin from H-kininogen. Ferritin does not interfere with the ability of kallikrein to digest a synthetic substrate, suggesting that ferritin specifically impedes the ability of kallikrein to digest H-kininogen, perhaps by steric hindrance. Based on these results, we propose a model of sequential H-kininogen cleavage and ferritin binding. These results are consistent with the hypothesis that the binding of ferritin to H-kininogen may serve to modulate bradykinin release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.