ArticleGenes and immunity2002
Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
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- Statistical Inference for High-Dimensional Generalized Linear Models with Binary Outcomes.Journal of the American Statistical Association · 2023Article
- Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs.Immunogenetics · 2016Article
- Inflammatory macrophage phenotype in BTBR T+tf/J mice.Frontiers in neuroscience · 2013Article
- Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium.Genes and immunity · 2009Article
- Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice.The Journal of clinical investigation · 2009Article
- NKG2D-RAE-1 receptor-ligand variation does not account for the NK cell defect in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Establishment of "The Gene Mine": a resource for rapid identification of complex trait genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.Diabetes · 2008Article
- Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease.Genes and immunity · 2004Article
- Qualitative and quantitative abnormalities in splenic dendritic cell populations in NOD mice.Clinical and experimental immunology · 2004Article
- Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient mice.Clinical and experimental immunology · 2003Article
- Definition of polymorphisms in the gene encoding the interleukin-12 receptor B1 subunit: testing linkage disequilibrium with Type I diabetes susceptibility.Genes and immunity · 2003Article
- Looking back and looking forward.Genes and immunity · 2003Article
- A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion.Genes and immunity · 2002Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (Il)-12 is a heterodimeric cytokine composed of 35 and 40 kD chains that plays a key role in the induction of Th1 cells, a T cell subset involved in many autoimmune diseases. We report here the cDNA sequence encoding the IL-12 p40 subunit from the autoimmune-prone non-obese diabetic (NOD) mouse, which spontaneously develops type 1 diabetes. Compared with the C57BL/6 sequence, there are two base changes that lead to amino acid replacements. Other autoimmune-prone strains, but not the diabetes-resistant NOR strain, share the same allele as NOD. We found both trans- and cis- allele-dependent effects on levels of basal and induced IL-12p40 expression. Furthermore, we show that one of these changes results in a structural change in the p40 molecule, as evidenced by the failure of a monoclonal antibody to bind NOD IL-12. These findings have implications for the predisposition to autoimmune responses in NOD and other autoimmune-prone mouse strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.