TGF-beta antagonists: why suppress a tumor suppressor?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation.Journal of clinical pathology · 2006
   Pooled it
2. Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018
   Trial
3. Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokinces on muscle regeneration.eLife · 2024
   Article
4. Sending a Message: Use of mRNA Vaccines to Target the Tumor Immune Microenvironment.Vaccines · 2023
   Review
5. Oridonin suppresses gastric cancer SGC-7901 cell proliferation by targeting the TNF-alpha/androgen receptor/TGF-beta signalling pathway axis.Journal of cellular and molecular medicine · 2023
   Article
6. Molecular Pathways and Mechanisms of TGFβ in Cancer Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
   Article
7. TGF-β Inhibitors for Therapeutic Management of Kidney Fibrosis.Pharmaceuticals (Basel, Switzerland) · 2022
   Review
8. TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies.Cells · 2022
   Review
9. Fibroblasts Influence the Efficacy, Resistance, and Future Use of Vaccines and Immunotherapy in Cancer Treatment.Vaccines · 2021
   Review
10. Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells.International journal of molecular sciences · 2021
    Article
11. TGFβ biology in cancer progression and immunotherapy.Nature reviews. Clinical oncology · 2021
    Review
12. Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer.Frontiers in oncology · 2020
    Review
13. Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation.Scientific reports · 2019
    Article
14. Misrepair in Context: TGFβ Regulation of DNA Repair.Frontiers in oncology · 2019
    Review
15. Periostin is a negative prognostic factor and promotes cancer cell proliferation in non-small cell lung cancer.Oncotarget · 2018
    Article
16. Clinical cancer research : an official journal of the American Association for Cancer Research · 2018
    Article
17. Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.Nature communications · 2018
    Article
18. Under-expression of LKB1 is associated with enhanced p38-MAPK signaling in human hepatocellular carcinoma.International journal of clinical and experimental pathology · 2018
    Article
19. Long noncoding RNA MALAT1 promotes cell proliferation through suppressing miR-205 and promoting SMAD4 expression in osteosarcoma.Oncotarget · 2017
    Article
20. The epigenetic regulation of CXCL14 plays a role in the pathobiology of oral cancers.Journal of Cancer · 2017
    Article

Corrections and comments

• Comment on
  Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.2002
• Comment on
  Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects.2002

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as