ArticleThe Journal of cell biology2002
Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 82 citations in OpenAlex.
- Functional omics of ORP7 in primary endothelial cells.BMC biology · 2024Article
- Atg8 family proteins, LIR/AIM motifs and other interaction modes.Autophagy reports · 2023Article
- Unlocking the gate to GABARAPL2.Biologia futura · 2022Review
- Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly?Handbook of experimental pharmacology · 2022Article
- Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition.International journal of molecular sciences · 2020Article
- Curvature-sensitive trans-assembly of human Atg8-family proteins in autophagy-related membrane tethering.Protein science : a publication of the Protein Society · 2020Article
- Article
- Multiple Functions of ATG8 Family Proteins in Plant Autophagy.Frontiers in cell and developmental biology · 2020Review
- Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs.The EMBO journal · 2019Article
- Insight into Notch Signaling Steps That InvolveGenetics · 2018Article
- Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.The EMBO journal · 2017Article
- Cargo recognition and trafficking in selective autophagy.Nature cell biology · 2014Review
- Article
- Cell cycle regulation of Golgi membrane dynamics.Trends in cell biology · 2013Review
- Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.Journal of virology · 2012Article
- The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle.Nature communications · 2011Article
- Atg8: an autophagy-related ubiquitin-like protein family.Genome biology · 2011Review
- Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8.The Journal of cell biology · 2010Article
- Reconstitution of the cell cycle-regulated Golgi disassembly and reassembly in a cell-free system.Nature protocols · 2010Article
- Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.The Journal of cell biology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Characterization of mammalian NSF (G274E) and Drosophila NSF (comatose) mutants revealed an evolutionarily conserved NSF activity distinct from ATPase-dependent SNARE disassembly that was essential for Golgi membrane fusion. Analysis of mammalian NSF function during cell-free assembly of Golgi cisternae from mitotic Golgi fragments revealed that NSF disassembles Golgi SNAREs during mitotic Golgi fragmentation. A subsequent ATPase-independent NSF activity restricted to the reassembly phase is essential for membrane fusion. NSF/alpha-SNAP catalyze the binding of GATE-16 to GOS-28, a Golgi v-SNARE, in a manner that requires ATP but not ATP hydrolysis. GATE-16 is essential for NSF-driven Golgi reassembly and precludes GOS-28 from binding to its cognate t-SNARE, syntaxin-5. We suggest that this occurs at the inception of Golgi reassembly to protect the v-SNARE and regulate SNARE function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.