ArticleAntimicrobial agents and chemotherapy2002
Antifungal triazoles and polymorphonuclear leukocytes synergize to cause increased hyphal damage to Scedosporium prolificans and Scedosporium apiospermum.
Article in Antimicrobial agents and chemotherapy, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Case Report: diagnosis of mixed Scedosporium apiospermum infection assisted by bronchoalveolar lavage fluid morphology.BMC pulmonary medicine · 2026Article
- Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections.Clinical microbiology reviews · 2024Review
- Non-Journal of fungi (Basel, Switzerland) · 2023Review
- Impact of Antifungal Compounds on Viability and Anti-Antimicrobial agents and chemotherapy · 2019Article
- Recent Advances in the Treatment of Scedosporiosis and Fusariosis.Journal of fungi (Basel, Switzerland) · 2018Review
- Answer to October 2017 Photo Quiz.Journal of clinical microbiology · 2017Article
- Granulocyte transfusions in the management of invasive fungal infections.British journal of haematology · 2017Review
- Interaction of platelets and anidulafungin against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2013Article
- Melanized fungi in human disease.Clinical microbiology reviews · 2010Review
- Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents.The Journal of infectious diseases · 2010Article
- Host immune response against Scedosporium species.Medical mycology · 2009Review
- Treatment options in emerging mold infections.Current infectious disease reports · 2008Article
- Infections caused by Scedosporium spp.Clinical microbiology reviews · 2008Review
- Expression of immunomodulatory genes in human monocytes induced by voriconazole in the presence of Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2007Article
- Combination treatment of invasive fungal infections.Clinical microbiology reviews · 2005Review
- Antifungal activities of posaconazole and granulocyte-macrophage colony-stimulating factor ex vivo and in mice with disseminated infection due to Scedosporium prolificans.Antimicrobial agents and chemotherapy · 2004Article
- Effect of granulocyte colony-stimulating factor combination therapy on efficacy of posaconazole (SCH56592) in an inhalation model of murine pulmonary aspergillosis.Antimicrobial agents and chemotherapy · 2004Article
- Micafungin enhances neutrophil fungicidal functions against Candida pseudohyphae.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scedosporium prolificans and Scedosporium apiospermum (Pseudallescheria boydii) cause pulmonary and disseminated infections refractory to most currently used antifungal agents in immunocompromised patients. We therefore investigated the potential antifungal activities of the triazoles itraconazole (ITC), voriconazole (VRC), and posaconazole (PSC) in combination with human polymorphonuclear leukocytes (PMNs) against the hyphae of these fungal pathogens. A colorimetric assay with (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]2H-tetrazolium-5-carboxanilide) sodium salt was used for the measurement of hyphal damage as an indicator of antifungal activity. We found that the newer triazoles VRC and PSC displayed synergistic effects with PMNs against S. prolificans hyphae after 24 h (P < 0.05), whereas the effect of ITC in combination with PMNs was additive (P < 0.01). All three triazoles displayed additive antifungal activities in combination with PMNs against S. apiospermum hyphae (P < 0.05). The synergistic or additive effects that these triazoles exhibited, combined with the antifungal activities of human PMNs, may have important therapeutic implications for the management of infections due to S. prolificans and S. apiospermum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.